RT Journal Article
ID 6d808fa84d2011cd
A1 Govindaraj, Ramar
A1 Paulraj, Michael Gabriel
A1 Toppo, Erenius
A1 Pandikumar, Perumal
A1 Ignacimuthu, Savarimuthu
A1 Al-Dhabi, Naif Abdhullah
T1 Hepatoprotective Effect of Tricholoma giganteum (Agaricomycetes) in a Nonalcoholic Fatty Liver Disease Rat Model
JF International Journal of Medicinal Mushrooms
JO IJM
YR 2016
FD 2016-10-19
VO 18
IS 8
SP 661
OP 669
K1 medicinal mushrooms
K1 metabolic syndrome
K1 natural products
K1 Tricholoma giganteum
AB Different concentrations of standardized ethanolic extract from the basidiocarps of Tricholoma giganteum Massee (TgEtOH) were screened for hepatoprotective effects in an animal model of rats with nonalcoholic fatty liver disease (NAFLD) fed a high-fat and high-fructose diet. After 4 weeks of treatment with TgEtOH, the relative liver weights, serum lipid concentrations, and biochemical profiles were found to be normal in treated animals compared with those given a standard drug. The macroscopic and histopathological studies clearly indicated that 200 mg/kg of ethanolic extract was effective in ameliorating the abnormalities of NAFLD. The findings indicate the efficacy of T. giganteum extract in liver protection. Future experiments on bioassay tailored fractionation of TgEtOH and mechanistic-based evaluation are required to assess the potential application of this mushroom as a food supplement in NAFLD.
PB Begell House
LK https://www.dl.begellhouse.com/journals/708ae68d64b17c52,34f197783d902eab,6d808fa84d2011cd.html