RT Journal Article ID 6d808fa84d2011cd A1 Govindaraj, Ramar A1 Paulraj, Michael Gabriel A1 Toppo, Erenius A1 Pandikumar, Perumal A1 Ignacimuthu, Savarimuthu A1 Al-Dhabi, Naif Abdhullah T1 Hepatoprotective Effect of Tricholoma giganteum (Agaricomycetes) in a Nonalcoholic Fatty Liver Disease Rat Model JF International Journal of Medicinal Mushrooms JO IJM YR 2016 FD 2016-10-19 VO 18 IS 8 SP 661 OP 669 K1 medicinal mushrooms K1 metabolic syndrome K1 natural products K1 Tricholoma giganteum AB Different concentrations of standardized ethanolic extract from the basidiocarps of Tricholoma giganteum Massee (TgEtOH) were screened for hepatoprotective effects in an animal model of rats with nonalcoholic fatty liver disease (NAFLD) fed a high-fat and high-fructose diet. After 4 weeks of treatment with TgEtOH, the relative liver weights, serum lipid concentrations, and biochemical profiles were found to be normal in treated animals compared with those given a standard drug. The macroscopic and histopathological studies clearly indicated that 200 mg/kg of ethanolic extract was effective in ameliorating the abnormalities of NAFLD. The findings indicate the efficacy of T. giganteum extract in liver protection. Future experiments on bioassay tailored fractionation of TgEtOH and mechanistic-based evaluation are required to assess the potential application of this mushroom as a food supplement in NAFLD. PB Begell House LK https://www.dl.begellhouse.com/journals/708ae68d64b17c52,34f197783d902eab,6d808fa84d2011cd.html