RT Journal Article ID 2491c81155ff42d6 A1 Chapelle, Dominique A1 Le Tallec, P. A1 Moireau, P. A1 Sorine, M. T1 ENERGY-PRESERVING MUSCLE TISSUE MODEL: FORMULATION AND COMPATIBLE DISCRETIZATIONS JF International Journal for Multiscale Computational Engineering JO JMC YR 2012 FD 2012-03-13 VO 10 IS 2 SP 189 OP 211 K1 muscle tissue modeling K1 myocardium K1 multiscale K1 energy balance K1 time and spacediscretizations AB In this paper, we propose a muscle tissue model-valid for striated muscles, in general, and for the myocardium, in particular-based on a multiscale physiological description. This model extends and refines an earlier-proposed formulation by allowing one to account for all major energy exchanges and balances, from the chemical activity coupled with oxygen supply to the production of actual mechanical work, namely, the biological function of the tissue. We thus perform a thorough analysis of the energy mechanisms prevailing at the various scales and proceed to propose a complete discretization strategy-in time and space-respecting the same balance laws. This will be crucial in future works to adequately model the many important physiological-normal and pathological-phenomena associated with these energy considerations. PB Begell House LK https://www.dl.begellhouse.com/journals/61fd1b191cf7e96f,42f1beba0b405e70,2491c81155ff42d6.html