RT Journal Article ID 1e424d301fbe59eb A1 Lu, Huanyu A1 Guo, Yue A1 Gupta, Gaurav A1 Tian, Xingsong T1 Mitogen-Activated Protein Kinase (MAPK): New Insights in Breast Cancer JF Journal of Environmental Pathology, Toxicology and Oncology JO JEP(T) YR 2019 FD 2019-01-18 VO 38 IS 1 SP 51 OP 59 K1 MAPK K1 breast cancer K1 mortality K1 PI3K-AKT signaling AB The eukaryotic cell cycle via mitogen-activated protein kinase (MAPK) has been considered as an effective signaling cascade pathway for anticancer therapy. In addition to the MAPK signaling pathway, the Rat Sarcoma Virus (Ras)/Rapidly Accelerated Fibrosarcoma (Raf)/MAPKā€“ERK kinase (MEK)/extracellular signal-regulated kinase (ERK) pathway is a signaling cascade that has a crucial role to play in cell survival and development of cancer, especially breast cancer. Novel drugs and clinical trials need to be investigated, taking into consideration the already studied genetic defects related to genesis of tumors in certain populations. The present review provides novel insights into current anticancerĀ treatments involving the MAPK pathway. PB Begell House LK https://www.dl.begellhouse.com/journals/0ff459a57a4c08d0,4b309b253eb144f8,1e424d301fbe59eb.html