RT Journal Article ID 1996a14119b5e716 A1 Tkachenko, Mikhail N. A1 Kotsuruba, Anatoliy V. A1 Bazilyuk, Olga V. A1 Gorot, Irina V. A1 Sagach, Vadim F. T1 Peculiarities of Changes of Vascular Reactivity and Reactive Forms of Oxygen in Conditions of Varying Duration of Permanent Stay in the Alienation Zone JF International Journal of Physiology and Pathophysiology JO IJPP YR 2011 FD 2011-03-01 VO 2 IS 1 SP 55 OP 68 K1 aorta K1 Chernobyl alienation zone K1 endothelium K1 nitric oxide K1 low doses of radiation K1 reactive forms of oxygen K1 reactive forms of nitrogen K1 uric acid K1 vascular reactivity AB Changes in the vascular reactivity and in the generation of reactive forms of oxygen and content of stable metabolites of nitric oxide (NO) were studied in the aorta preparations of C57B1/6 and BALB/c mice of the two age groups (6 and 18 mo.), which were born and permanently kept in the Chernobyl alienation zone. The results obtained showed a disturbance of acetylcholine-induced endothelium-dependent reactions of relaxation of smooth muscles of the thoracic aorta. A lower level of oxidative NO synthesis and lower level of nonoxidative arginase metabolism of arginine corresponded to a higher degree of damage of endothelium- dependent reactions of relaxation of the thoracic aorta smooth muscles. A decrease of oxidative NO synthesis in conditions of permanent effects of low doses of radiation was depend on an increase of generation of reactive forms of oxygen, namely, superoxide and hydroxyl radicals, which might be formed in mitochondria. In conditions of permanent effects of low doses of radiation a lesser level of protein nitrosylation, same as lesser one of generation of OH-radical, corresponded to a higher level of damage of endothelium-dependent reactions. PB Begell House LK https://www.dl.begellhouse.com/journals/6ec4ba27650016b1,4233e80d10b9a4d1,1996a14119b5e716.html