RT Journal Article ID 12f04c0f40e1d6da A1 Senyuk, Olga F. A1 Gorovoj, Leontij F. A1 Beketova, Galina V. A1 Savichuk, Nataliya O. A1 Rytik, Petr G. A1 Kucherov, Igor I. A1 Prilutckaya, Alla B. A1 Prilutsky, Alexandr I. T1 Anti-Infective Properties of the Melanin-Glucan Complex Obtained from Medicinal Tinder Bracket Mushroom, Fomes fomentarius (L.: Fr.) Fr. (Aphyllophoromycetideae) JF International Journal of Medicinal Mushrooms JO IJM YR 2011 FD 2011-03-22 VO 13 IS 1 SP 7 OP 18 K1 medicinal mushrooms K1 Fomes fomentarius K1 Helicobacter pylori K1 Candida albicans K1 Herpes vulgaris K1 melanins K1 glucans K1 chitin K1 antimicrobial K1 antiviral K1 fungicidal effects AB The goal of this investigation was to comparatively study the efficiency of traditionally used anti-infective drugs and biopolymer complexes originated from the medicinal mushroom Fomes fomentarius (L.:Fr.) Fr.: 1) water-soluble melanin-glucan complex (MGC; ∼80% melanins and ∼20% Β-glucans) and 2) insoluble chitin-glucan-melanin complex (ChGMC; ∼70% chitin, ∼20% Β-glucans, and ∼10% melanins). Infectious materials (Helicobacter pylori, Candida albicans, and Herpes vulgaris I and HIV-1zmb) were used in pure cultures of in vitro and in vivo models on experimental animals. Comparison studies of fungal biopolymers and effective modern antifungal, antibacterial, and antiviral drugs were used in in vitro models. The comparative clinical efficiency of ChGMC and of etiotropic pharmaceuticals in models of H. pylori, C. albicans, and H. vulgaris I infection contamination were studied. Using in vitro models, it was established that MGC completely depresses growth of C. albicans. MGC had an antimicrobial effect on H. pylori identical to erythromycin in all concentrations, and had a stronger action on this bacterium than other tested antibiotics. Tested MGC possesses simultaneously weak toxicity and high anti-HIV-1 activity in comparison with zidovudine (Retrovir). The obtained results show that CLUDDT therapy in Wistar rats with the application of ChGMC is, on average, 1.35−1.43 times as effective as a traditional one. Considering the absence of MGC and ChGMC toxic properties on blood cells even in very high concentrations, these complexes may be used as a source of biopolymers for the creation of essentially new agents for wide application in infectious pathology. PB Begell House LK https://www.dl.begellhouse.com/journals/708ae68d64b17c52,77c52f4810e4b47b,12f04c0f40e1d6da.html