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International Journal of Medicinal Mushrooms
Импакт фактор: 1.423 5-летний Импакт фактор: 1.525 SJR: 0.431 SNIP: 0.716 CiteScore™: 2.6

ISSN Печать: 1521-9437
ISSN Онлайн: 1940-4344

Выпуски:
Том 22, 2020 Том 21, 2019 Том 20, 2018 Том 19, 2017 Том 18, 2016 Том 17, 2015 Том 16, 2014 Том 15, 2013 Том 14, 2012 Том 13, 2011 Том 12, 2010 Том 11, 2009 Том 10, 2008 Том 9, 2007 Том 8, 2006 Том 7, 2005 Том 6, 2004 Том 5, 2003 Том 4, 2002 Том 3, 2001 Том 2, 2000 Том 1, 1999

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v13.i1.20
pages 7-18

Anti-Infective Properties of the Melanin-Glucan Complex Obtained from Medicinal Tinder Bracket Mushroom, Fomes fomentarius (L.: Fr.) Fr. (Aphyllophoromycetideae)

Olga F. Senyuk
Institute for Problems of Nuclear Power Plant Safety, Chernobyl, Ukraine
Leontij F. Gorovoj
Institute of Cell Biology and Genetic Engineering NAS of Ukraine, 148 Zabolotnogo Str. Kiev, 03680 Ukraine
Galina V. Beketova
Kiev Medical Academy of Postdegree Education
Nataliya O. Savichuk
Kiev Medical Academy of Postdegree Education
Petr G. Rytik
Research Institute for Epidemiology and Microbiology, Minsk
Igor I. Kucherov
Research Institute for Epidemiology and Microbiology, Minsk
Alla B. Prilutckaya
A. Bogomolec National Medical University, 13 Taras Shevchenko Parkway, Kiev, Ukraine
Alexandr I. Prilutsky
National Medical University, Kiev

Краткое описание

The goal of this investigation was to comparatively study the efficiency of traditionally used anti-infective drugs and biopolymer complexes originated from the medicinal mushroom Fomes fomentarius (L.:Fr.) Fr.: 1) water-soluble melanin-glucan complex (MGC; ∼80% melanins and ∼20% Β-glucans) and 2) insoluble chitin-glucan-melanin complex (ChGMC; ∼70% chitin, ∼20% Β-glucans, and ∼10% melanins). Infectious materials (Helicobacter pylori, Candida albicans, and Herpes vulgaris I and HIV-1zmb) were used in pure cultures of in vitro and in vivo models on experimental animals. Comparison studies of fungal biopolymers and effective modern antifungal, antibacterial, and antiviral drugs were used in in vitro models. The comparative clinical efficiency of ChGMC and of etiotropic pharmaceuticals in models of H. pylori, C. albicans, and H. vulgaris I infection contamination were studied. Using in vitro models, it was established that MGC completely depresses growth of C. albicans. MGC had an antimicrobial effect on H. pylori identical to erythromycin in all concentrations, and had a stronger action on this bacterium than other tested antibiotics. Tested MGC possesses simultaneously weak toxicity and high anti-HIV-1 activity in comparison with zidovudine (Retrovir). The obtained results show that CLUDDT therapy in Wistar rats with the application of ChGMC is, on average, 1.35−1.43 times as effective as a traditional one. Considering the absence of MGC and ChGMC toxic properties on blood cells even in very high concentrations, these complexes may be used as a source of biopolymers for the creation of essentially new agents for wide application in infectious pathology.


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