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International Journal of Medicinal Mushrooms
Импакт фактор: 1.423 5-летний Импакт фактор: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN Печать: 1521-9437
ISSN Онлайн: 1940-4344

Выпуски:
Том 21, 2019 Том 20, 2018 Том 19, 2017 Том 18, 2016 Том 17, 2015 Том 16, 2014 Том 15, 2013 Том 14, 2012 Том 13, 2011 Том 12, 2010 Том 11, 2009 Том 10, 2008 Том 9, 2007 Том 8, 2006 Том 7, 2005 Том 6, 2004 Том 5, 2003 Том 4, 2002 Том 3, 2001 Том 2, 2000 Том 1, 1999

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v4.i4.60
7 pages

Antioxidant, Anti-inflammatory, and Antitumor Activities of Culinary-Medicinal Mushroom Pleurotus pufmonanus (Fr.) Quel. (Agaricomycetideae)

Nayana Jose
Amala Cancer Research Centre, Amala Nagar, Thrissur 680 553, Kerala, India
Thekkuttuparambil Ananthanarayanan Ajith
Department of Biochemistry, Amala Institute of Medical Sciences, Amala Nagar, Thrissur, Kerala, India
Kainoor K. Janardhanan
Department of Microbiology, Amala Cancer Research Centre, Amala Nagar, Thrissur, Kerala, India

Краткое описание

Antioxidant, antitumor, and anti-inflammatory activities of the methanol extract of Pleurotus pulmonarius (Fr.) Quel [= P. sajor-caju (Fr.) Singer] were evaluated. The methanol extract of P. pulmonarius showed significant hydroxyl radical-scavenging and lipid peroxidation-inhibiting activities; the concentrations required for 50% inhibition (IC50) were 476.67 and 960.0 mg/mL, respectively. However, the extract did not show superoxide radical-scavenging activity. The administration of the extract caused significant regression of solid tumor at concentrations of 250, 500, and 1000 mg/kg body weight. The extract was also significantly effective in reducing paw edema induced by carrageenan and formalin at concentrations of 500 and 1000 mg/kg body weight. In both the antitumor and anti-inflammatory models, the activity of the extracts was comparable to the standard reference drugs, cisplatin and diclofenac, respectively. The results thus suggest therapeutic potential for P. pulmonarius as an antitumor and anti-inflammatory agent.


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