Доступ предоставлен для: Guest
Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции
International Journal of Medicinal Mushrooms
Импакт фактор: 1.423 5-летний Импакт фактор: 1.525 SJR: 0.433 SNIP: 0.661 CiteScore™: 1.38

ISSN Печать: 1521-9437
ISSN Онлайн: 1940-4344

Выпуски:
Том 21, 2019 Том 20, 2018 Том 19, 2017 Том 18, 2016 Том 17, 2015 Том 16, 2014 Том 15, 2013 Том 14, 2012 Том 13, 2011 Том 12, 2010 Том 11, 2009 Том 10, 2008 Том 9, 2007 Том 8, 2006 Том 7, 2005 Том 6, 2004 Том 5, 2003 Том 4, 2002 Том 3, 2001 Том 2, 2000 Том 1, 1999

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v4.i4.70
6 pages

Effects of Total Triterpenoids Extract from Ganoderma Iucidum (Curt.: Fr.) P. Karst. (Reishi Mushroom) on Experimental Liver Injury Models Induced by Carbon Tetrachloride or D-Galactosamine in Mice

Zhi-Bin Lin
Department of Pharmacology, School of Basic Medical Sciences, Beijing University, Beijing 100083, P. R. China
Ming-Yu Wang
Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, 100083. People's Republic of China
Qiang Liu
Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, 100083. People's Republic of China
Qing-Ming Che
Department of Traditional Chinese Medicine Drugs, College of Pharmacy, Peking University, Beijing, 100083. People's Republic of China

Краткое описание

The effect of total triterpenoids extract isolated from Ganoderma lucidum (Curt.: Fr.) P. Karst. (GT) on two different experimental liver injury models induced by carbon tetrachloride (CCl4) and D-galactosamine (D-Gal) was studied in mice. The liver triglycerides (TG), superoxide dismutase (SOD), glutathione (GSH), malondialdehyde (MDA), and serum alanine aminotransferase (ALT) were measured. The histopathological changes in the liver were assayed in mice. The results were as follows: GT (80 mg/kg) and GT2 (10, 20, 40 mg/ kg), as malotilate, were shown to significantly inhibit the increase of serum ALT and liver TG levels in the models. GT could antagonize the decrease of SOD activity and liver GSH content and inhibit the increase of the liver MDA content in the liver-injury mice induced by CCl4 or D-Gal. Also, it could improve the histopathological changes of liver injury. The results demonstrate that total triterpenoids isolated from G. lucidum have powerful protective effects against liver damage induced by CCl4 or D-Gal. Their hepato-protective effects were perhaps related to the ability to promote the activity of scavenging enzymes for hepatic free radicals in mice, and thus to raise the ability of antioxidation in mice.


Articles with similar content:

Antioxidant and Hepatoprotective Effects of Crataegus songarica Methanol Extract
Journal of Environmental Pathology, Toxicology and Oncology, Vol.33, 2014, issue 2
Akbar Masood, Ovais Zargar, Mohammad Afzal Zargar, Showkat Ahmad Ganie, Shajrul Amin, Parvaiz Ahmad Dar, Shayaq Ul Abeer, Rabia Hamid, Tanveer Ali Dar, Bilal Zargar
Protective Effects of Picorrhiza Kurroa Extract against 2-Acetylaminofluorene-Induced Hepatotoxicity in Wistar Rats
Journal of Environmental Pathology, Toxicology and Oncology, Vol.26, 2007, issue 3
Sarwat Sultana, Sahar Rahman
Hepatoprotective Effects of Aqueous Extract from Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidum (Higher Basidiomycetes) on α-Amanitin−Induced Liver Injury in Mice
International Journal of Medicinal Mushrooms, Vol.15, 2013, issue 4
Jinsong Hu, Xin Wu, Jun Zeng, Qiong Liao, Zuohong Chen, Rong Zhou, Ping Zhang
The Protective Effects of Aqueous Extracts of Wild-Growing and Fermented Royal Sun Mushroom, Agaricus brasiliensis S. Wasser et al. (Higher Basidiomycetes), in CCl4-Induced Oxidative Damage in Rats
International Journal of Medicinal Mushrooms, Vol.14, 2012, issue 6
Haitao Yu, Baosheng Zhao, Chunchao Han, Chunjing Zhang
Hepatoprotection of Gentiana scabra Extract and Polyphenols in Liver of Carbon Tetrachloride-Intoxicated Mice
Journal of Environmental Pathology, Toxicology and Oncology, Vol.30, 2011, issue 3
Jyun-Han Chen, Lean Teik Ng, Huey-Jiun Ko