Доступ предоставлен для: Guest
Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции
International Journal of Medicinal Mushrooms
Импакт фактор: 1.423 5-летний Импакт фактор: 1.525 SJR: 0.433 SNIP: 0.661 CiteScore™: 1.38

ISSN Печать: 1521-9437
ISSN Онлайн: 1940-4344

Выпуски:
Том 21, 2019 Том 20, 2018 Том 19, 2017 Том 18, 2016 Том 17, 2015 Том 16, 2014 Том 15, 2013 Том 14, 2012 Том 13, 2011 Том 12, 2010 Том 11, 2009 Том 10, 2008 Том 9, 2007 Том 8, 2006 Том 7, 2005 Том 6, 2004 Том 5, 2003 Том 4, 2002 Том 3, 2001 Том 2, 2000 Том 1, 1999

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.v1.i1.20
pages 9-29

The Extraction and Development of Antitumor-Active Polysaccharides from Medicinal Mushrooms in Japan (Review)

Takashi Mizuno
Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University, 4-13-9 Seinan-Cho, Fujieda-Shi 426-0063, Japan

Краткое описание

It has been known for many years that most mushrooms with known effects against cancer belong to the family Polyporaceae s.l. (Agaricales s.l.). However, the components responsible for such action have not been clearly defined. In Japan, in 1968, a hot water extract from some edible mushrooms belonging to the family Polyporaceae s.l., showed a marked host-mediated antitumor activity. Since then, numerous researchers have isolated active polysaccharides and have identified them to be (1→3)-β-D-glucopyranans with a (1→6)-β-D-glucosyl branch containing protein. Several antitumor polysaccharides, some hetero-β-glucans and their protein complexes, such as xyloglucans and acidic β-glucan containing uronic acid, are insoluble in water. They were, however, isolated from the extracts using large amounts of dilute alkali with Japanese (8 species) and Chinese (5 species) mushrooms. Several trials have been made to enhance activity by chemical modification, such as polyalcohols formed by a mild Smith degradation and the products formed by BH4-reduction after 104-oxidation. Mushroom polysaccharides are considered to be biological response modifiers (BRM), or immunopotentiators, because of their action mechanism. In Japan, three different polysaccharide antitumor agents have been developed from the fruit body, mycelium, and cultured medium, of three mushroom species.


Articles with similar content:

A Review of Pharmacological Activities of Mushroom Polysaccharides
International Journal of Medicinal Mushrooms, Vol.1, 1999, issue 3
Vincent Eng Choo Ooi, Fang Liu
Medicinal Properties of Substances Occurring in Higher Basidiomycetes Mushrooms: Current Perspectives (Review)
International Journal of Medicinal Mushrooms, Vol.1, 1999, issue 1
Solomon P. Wasser, Alexander L. Weis
Beneficial Effects of Edible and Medicinal Mushrooms on Health Care
International Journal of Medicinal Mushrooms, Vol.3, 2001, issue 4
Tetsuro Ikekawa
Medicinal Mushroom Science: History, Current Status, Future Trends, and Unsolved Problems
International Journal of Medicinal Mushrooms, Vol.12, 2010, issue 1
Solomon P. Wasser
Therapeutic Effects of Substances Occurring in Higher Basidiomycetes Mushrooms: A Modern Perspective
Critical Reviews™ in Immunology, Vol.19, 1999, issue 1
Solomon P. Wasser, Alexander L. Weis