Доступ предоставлен для: Guest
Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции
International Journal of Medicinal Mushrooms
Импакт фактор: 1.423 5-летний Импакт фактор: 1.525 SJR: 0.431 SNIP: 0.716 CiteScore™: 2.6

ISSN Печать: 1521-9437
ISSN Онлайн: 1940-4344

Выпуски:
Том 22, 2020 Том 21, 2019 Том 20, 2018 Том 19, 2017 Том 18, 2016 Том 17, 2015 Том 16, 2014 Том 15, 2013 Том 14, 2012 Том 13, 2011 Том 12, 2010 Том 11, 2009 Том 10, 2008 Том 9, 2007 Том 8, 2006 Том 7, 2005 Том 6, 2004 Том 5, 2003 Том 4, 2002 Том 3, 2001 Том 2, 2000 Том 1, 1999

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.2018025445
pages 155-163

Cell Proliferation and DNA Repair Ability of Ganoderma neo-japonicum (Agaricomycetes): An Indigenous Medicinal Mushroom from Malaysia

Wee Cheat Tan
Mushroom Research Centre, University of Malaya, Kuala Lumpur, Malaysia; Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia
Umah Rani Kuppusamy
Mushroom Research Centre, University of Malaya, 50603 Kuala Lumpur, Malaysia; Department of Biomedical Science, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
Chia Wei Phan
Mushroom Research Centre, University of Malaya, Kuala Lumpur, Malaysia; Department of Pharmacy, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
Vikineswary Sabaratnam
Mushroom Research Centre, University of Malaya, 50603 Kuala Lumpur, Malaysia; Institute of Biological Science, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia

Краткое описание

Ganoderma neo-japonicum is an annual polypore that grows on decaying bamboo in the forests of Malaysia. The indigenous Temuan tribe uses this species as a medicinal mushroom to cure fever and epilepsy and to improve body strength. The potential use of G. neo-japonicum in genoprotection and DNA repair was established using a single-cell gel electrophoresis (comet) assay. The effects of the ethanol and hot aqueous extracts from wild and cultivated basidiocarps, solid substrate-fermented (SSF) wheat grains, and mycelia via submerged culture on H2O2-damaged murine RAW264.7 macrophages were investigated. An ethanol extract from wild basidiocarps showed the most significant protective effect on murine RAW264.7 macrophages, followed by ethanol and hot water extracts of cultivated basidiocarps, and this effect was dose dependent. However, only the ethanol extracts from SSF and submerged culture showed significant protective effects compared with the control. As for DNA repair ability, only the ethanol extract from wild and cultivated basidiocarps showed significant results when compared with the negative control. The findings suggest the potential therapeutic use of G. neo-japonicum in genome protection and as a DNA repair stimulator.


Articles with similar content:

Genoprotective Activity of Edible and Medicinal Mushroom Components
International Journal of Medicinal Mushrooms, Vol.6, 2004, issue 1
Anthony E. James, John A. Buswell, Yu-ling Shi, Iris F. F. Benzie
Genoprotective Capacity of Alternatively Cultivated Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), Basidiocarps
International Journal of Medicinal Mushrooms, Vol.18, 2016, issue 12
Vladan Bajic, Jelena Vukojević, Lada Živković, Mirjana Stajic, Jasmina Ćilerdžić, Biljana Spremo-Potparević
Antioxidant and Anti-Inflammatory Potential of Shiitake Culinary-Medicinal Mushroom, Lentinus edodes (Agaricomycetes), Sporophores from Various Culture Conditions
International Journal of Medicinal Mushrooms, Vol.22, 2020, issue 6
Ibrahima Diallo, Caroline Guzman, Françoise Fons, Nathalie Saint, Lonsény Traoré, Patrick Poucheret, Manon Vitou, Frédéric Boudard, Alain Michel, Sylvie Rapior, Sylvie Morel
Anti-inflammatory and Free Radical Scavenging Activities of Polysaccharide−Protein Complex Isolated from Phellinus rimosus (Berk.) Pilát (Aphyllophoromycetideae)
International Journal of Medicinal Mushrooms, Vol.11, 2009, issue 4
Kainoor K. Janardhanan, Ram A. Vishwakarma, Chakrapully R. Meera, Balan Nitha
Effects of Various Treatments on Extraction of the Main Bioactive Components and Determination of Biological Activity of Extracts from the Caterpillar Medicinal Mushroom Cordyceps militaris (Ascomycetes)
International Journal of Medicinal Mushrooms, Vol.20, 2018, issue 9
Chaomin Yin, Hong Gao, Xiuzhi Fan, De-Fang Shi, Zhe Fan