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ISSN Печать: 1521-9437
ISSN Онлайн: 1940-4344
IF:
1.2
5-Year IF:
1.4
Immediacy Index:
0.3
Eigenfactor:
0.00066
JCI:
0.34
SJR:
0.274
SNIP:
0.41
CiteScore™::
2.8
H-Index:
37
Indexed in
Comparison of the Immunomodulating Activities of 1,3-β-glucan Fractions from the Culinary-Medicinal Mushroom Sparassis crispa Wulf.:Fr. (Aphyllophoromycetideae)
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Краткое описание
Sparassis crispa is a culinary-medicinal mushroom recently cultivated in Japan, China, Germany, and the U.S. In a previous study, we purified a 6-branched 1,3-β-D-glucan preparation, designated as SCG, and investigated its biological activities. In the present study, we prepared polysac-charide fractions extracted from S. crispa by hot water (SCHWE), cold NaOH (SCG), and hot NaOH (SCHA), and investigated their properties and immunomodulating activities. These polysaccharide fractions showed strong limulus factor G activity due to the presence of β-1,3-D-glucans. They also showed a strong antitumor activity against the solid form of Sarcoma 180 in ICR mice, and hemato-poietic response in cyclophosphamide-induced leukopenic mice. They induced the splenocytes from DBA/2 mice to produce GM-CSF, TNF-α, and IFN-γ in vitro. By treatment with sodium hydroxide of SCHWE, the hematopietic response was enhanced but cytokine induction was decreased. Taken together, these results strongly suggested that the preparation method was related to the conformation of the β-glucan fraction, and the immunomodulating activities in vivo and in vitro were significantly modulated by the preparation methods.
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Hida Toshie H., Kawaminami Hiromi, Ishibashi Ken-ichi, Miura Noriko N., Adachi Yoshiyuki, Yadomae Toshiro, Ohno Naohito, Effect of GM-CSF on cytokine induction by soluble β-glucan SCGin vitroin β-glucan-treated mice, Microbiology and Immunology, 53, 7, 2009. Crossref
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Harada Toshie, Ohno Naohito, Contribution of dectin-1 and granulocyte macrophage–colony stimulating factor (GM-CSF) to immunomodulating actions of β-glucan, International Immunopharmacology, 8, 4, 2008. Crossref
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Harada Toshie, Miura Noriko N., Adachi Yoshiyuki, Nakajima Mitsuhiro, Yadomae Toshiro, Ohno Naohito, Highly Expressed Dectin-1 on Bone Marrow-Derived Dendritic Cells Regulates the Sensitivity to β-Glucan in DBA/2 Mice, Journal of Interferon & Cytokine Research, 28, 8, 2008. Crossref
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Zhang Xiaorui, Qi Chunhui, Guo Yan, Zhou Wenxia, Zhang Yongxiang, Toll-like receptor 4-related immunostimulatory polysaccharides: Primary structure, activity relationships, and possible interaction models, Carbohydrate Polymers, 149, 2016. Crossref
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Ryoo Rhim, Sou Hong-Duck, Ka Kang-Hyeon, Park Hyun, Elicitor-induced β-glucan contents in fruit body of cauliflower mushroom (Sparassis latifolia), Forest Science and Technology, 14, 3, 2018. Crossref
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Seo Seung-Ho, Park Seong-Eun, Kim Eun-Ju, Son Hong-Seok, GC–MS based metabolomics study of fermented stipe of Sparassis crispa, Food Science and Biotechnology, 27, 4, 2018. Crossref
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Kim Yong-Woon, Wu Yuanzheng, Choi Moon-Hee, Shin Hyun-Jae, Li Jishun, Alginate-Derived Elicitors Enhance β-Glucan Content and Antioxidant Activities in Culinary and Medicinal Mushroom, Sparassis latifolia, Journal of Fungi, 6, 2, 2020. Crossref
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González N., Oliva S., Ramírez K., Rodriguez C., Sánchez S., Paz M., Determinación De La Actividad Inmunomoduladora De Losbasidiomicetos Comestibles: Cantharellus lateritius Singer (Berk) Singer, Armillariella polymyces (Pers.: Letell.) Sing & Clem, Lacearía amethystina Cooke, Lactarias deliciosas (L. ex Fr) S. F. Gray y Pleurotos ostreatus (Jacquini ex Fries) Kummer, Revista Científica, 18, 1, 2010. Crossref