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Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции
International Journal of Medicinal Mushrooms
Импакт фактор: 1.423 5-летний Импакт фактор: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN Печать: 1521-9437
ISSN Онлайн: 1940-4344

Выпуски:
Том 21, 2019 Том 20, 2018 Том 19, 2017 Том 18, 2016 Том 17, 2015 Том 16, 2014 Том 15, 2013 Том 14, 2012 Том 13, 2011 Том 12, 2010 Том 11, 2009 Том 10, 2008 Том 9, 2007 Том 8, 2006 Том 7, 2005 Том 6, 2004 Том 5, 2003 Том 4, 2002 Том 3, 2001 Том 2, 2000 Том 1, 1999

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v3.i4.80
34 pages

Higher Basidiomycota as a Source of Antitumor and Immunostimulating Polysaccharides (Review)

Sergey V. Reshetnikov
N. G. Kholodny Institute of Botany, National Academy of Sciences of Ukraine, 2 Tereshchenkivskaya Str., Kiev 252001, Ukraine; and Med Myco Ltd., Institute of Evolution, University of Haifa, Mt. Carmel, Haifa 31905, Israel
Kok- Kheng Tan
MycoBiotech Pte Ltd 12 Science Park Drive # 04-01 The Mendel- Singapore Science Park 1 118 225, Singapore

Краткое описание

Higher Basidiomycota mushrooms arc unlimited sources of anticancer and immunostimulating polysaccharides. Many if not all Basidiomycota mushrooms contain biologically active polysaccharides. The data about mushrooms containing such polysaccharides are summarized. Six hundred and fifty-one species and 7 intraspecific taxa from 182 genera of higher Hetero- and Homobasidiomycetes contain pharmacologically active polysaccharides. Fruiting bodies, culture mycelium, and culture broth are sources of antitumor polysaccharides. The present review includes the data on the chemical structure of primary types of biologically active polysaccharides found in mushrooms. From 10 to 30 fractions of polysaccharides can be extracted from mushroom material, and most of them demonstrated antitumor activity. Special attention is turned to comparative analysis of polysaccharide fraction composition in fruiting bodies and culture mycelia of the same species. It is shown in examples of Agaricus blazei, Ganoderma tsugae, and Grifola frondosa that antitumor polysaccharides obtained from fruiting bodies, culture mycelia. or produced in a culture medium have a different chemical structure, and some polysaccharides developed in pure culture conditions were never found in fruiting bodies. Fractionation procedures for polysaccharide extraction and methods of their activation by chemical modification arc reviewed.


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