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International Journal of Medicinal Mushrooms
Импакт фактор: 1.423 5-летний Импакт фактор: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN Печать: 1521-9437
ISSN Онлайн: 1940-4344

Выпуски:
Том 21, 2019 Том 20, 2018 Том 19, 2017 Том 18, 2016 Том 17, 2015 Том 16, 2014 Том 15, 2013 Том 14, 2012 Том 13, 2011 Том 12, 2010 Том 11, 2009 Том 10, 2008 Том 9, 2007 Том 8, 2006 Том 7, 2005 Том 6, 2004 Том 5, 2003 Том 4, 2002 Том 3, 2001 Том 2, 2000 Том 1, 1999

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v4.i2.40
14 pages

Biological Activity of Cordyceps (Fr.) Link Species (Ascomycetes) Derived from a Natural Source and from Fermented Mycelia on Diabetes in STZ-Induced Rats

Tai-Hao Hsu
Department of Medicinal Botanicals and Health Applications, Da-Yeh University, Datsuen, Changhua, 51591, Taiwan (R. O. C.); Department of Bioindustry Technology, Da-Yeh University, Datsuen, Changhua, 51591, Taiwan (R. O. C.)
Hui-Chen Lo
Department of Nutritional Science, Fu Jen Catholic University, New Taipei City, Taiwan

Краткое описание

The Chinese traditional herb medicine Cordyceps (natural source) and the mycelial preparations of different species of genus Cordyceps (Fr.) Link (fermented mycelia) produced by fermentation, as well as a commercial product, have been compared in terms of biological activity of in a diabetic animal model using STZ-induced rats. The respective changes of several indices in serum substrate levels and blood analysis, and relative organ weights, were characterized to judge the ability of these preparations of meliorating diabetes by the consecutive intake intragastrically for 14 days. There were significant differences statistically both in the daily average water intake and the daily average urine volume of the STZ-treated group with naturally produced of Cordyceps compared to those of the fermentated mycelial preparations. Although there were no differences in plasma glucose levels among between the Cordyceps-treated group and that of the Cordyceps-untreated STZ rats, all the values of glucose, albumin, cholesterol, HDLcholesterol, triglycerides, BUN in serum, and WBC, RBC, Ht, and MCH in the blood for of the Cordyceps-treated diabetic rats are were between those of the Cordyceps-untreated diabetic rats and the control group. The effects of all the Cordyceps preparations were not reflected in changes of relative organ weight of the rats. This combination of events suggested that a mild and inconspicuous improvement of severe diabetes in STZ-treated rats with the Cordyceps preparations under the experimental conditions. In general, there were no differences between the naturally produced and fermented mycelia of Cordyceps in alleviating diabetes in the present experiments.


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