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International Journal of Medicinal Mushrooms
Импакт фактор: 1.423 5-летний Импакт фактор: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN Печать: 1521-9437
ISSN Онлайн: 1940-4344

Выпуски:
Том 21, 2019 Том 20, 2018 Том 19, 2017 Том 18, 2016 Том 17, 2015 Том 16, 2014 Том 15, 2013 Том 14, 2012 Том 13, 2011 Том 12, 2010 Том 11, 2009 Том 10, 2008 Том 9, 2007 Том 8, 2006 Том 7, 2005 Том 6, 2004 Том 5, 2003 Том 4, 2002 Том 3, 2001 Том 2, 2000 Том 1, 1999

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v16.i2.80
pages 179-187

Inhibitory Activity of Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Higher Basidiomycetes) on Transformed Cells by Human Papillomavirus

Eva Hernandez-Marquez
Center of Research on Infectious Disease, National Institute of Public Health, 655 University Ave, CP. 62100, Cuernavaca, Morelos, Mexico
Alfredo Lagunas-Martinez
Center of Research on Infectious Disease, National Institute of Public Health, 655 University Ave, CP. 62100, Cuernavaca, Morelos, Mexico
Victor H. Bermudez-Morales
Center of Research on Infectious Disease, National Institute of Public Health, 655 University Ave, CP. 62100, Cuernavaca, Morelos, Mexico
Ana I. Burgete-Garcfa
Center of Research on Infectious Disease, National Institute of Public Health, 655 University Ave, CP. 62100, Cuernavaca, Morelos, Mexico
Ismael Leon-Rivera
Centro de Investigaciones Quimicas, Universidad Autonoma del Estado de Morelos, Avenida Universidad 1001, Col. Chamilpa 62209 Cuernavaca, Morelos, México. www.ciq.uaem.mx/
Elizur Montiel-Arcos
Centro de Investigaciones Biologicas, Universidad Autonoma del Estado de Morelos, Avenida Universidad 1001, Col. Chamilpa 62209 Cuernavaca, Morelos, México
Enrique Garcia-Villa
Department of Genetics and Molecular Biology, CINVESTAV-IPN, Mexico City, Mexico
Patricio Gariglio
Department of Genetics and Molecular Biology, CINVESTAV-IPN, Mexico City, Mexico
Vicente Madrid-Marina V.
Center of Research on Infectious Disease, National Institute of Public Health, 655 University Ave, CP. 62100, Cuernavaca, Morelos, Mexico
Raul N. Ondarza-Vidaurreta
Center of Research on Infectious Disease, National Institute of Public Health, 655 University Ave, CP. 62100, Cuernavaca, Morelos, Mexico; National Autonomous University of Mexico, University City, Mexico City 04510, Mexico

Краткое описание

In this study, we investigated the effects of the aqueous extracts of Lingzhi or Reishi medicinal mushroom, Ganoderma lucidum, obtained from three localities (China; and Morelos and Michoacan, Mexico) on cervical cells transformed by human papillomavirus (HeLa and SiHa) and C-33A cancer cells. The cells were plated in DMEM medium supplemented, and were incubated in the presence of different concentrations of G. lucidum for 24 h. Cell proliferation was determined by MTT colorimetric assay and viability by trypan blue assay. Inhibitory dose was determined (IC50) of the three different extracts of G. lucidum in the culture cell lines mentioned above. The apoptosis process was confirmed by nuclear DNA fragmentation and the cell cycle was determined by flow cytometry. The results showed that aqueous extracts G. lucidum obtained from three localities produced inhibition in the proliferation of VPH transformed cells; they also induced apoptosis and cell cycle arrest in HeLa, SiHa, and C-33A cancer cells. Therefore, it was found that aqueous extracts G. lucidum obtained from three different locations produced inhibitory effect on cancer cells and may have a potential therapeutic use for the prevention and treatment of this disease.


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