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International Journal of Medicinal Mushrooms
Импакт фактор: 1.423 5-летний Импакт фактор: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN Печать: 1521-9437
ISSN Онлайн: 1940-4344

Выпуски:
Том 21, 2019 Том 20, 2018 Том 19, 2017 Том 18, 2016 Том 17, 2015 Том 16, 2014 Том 15, 2013 Том 14, 2012 Том 13, 2011 Том 12, 2010 Том 11, 2009 Том 10, 2008 Том 9, 2007 Том 8, 2006 Том 7, 2005 Том 6, 2004 Том 5, 2003 Том 4, 2002 Том 3, 2001 Том 2, 2000 Том 1, 1999

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.2017024498
pages 991-1000

Characterization of the Effects of the Shiitake Culinary-Medicinal Mushroom, Lentinus edodes (Agaricomycetes), on Severe Gestational Diabetes Mellitus in Rats

Bianca Hessel Maschio
Post Graduate Program in Pharmaceutical Sciences, Department of Development and Evaluation of Bioactive Substances, University of Sorocaba, SP, Brazil; Laboratory of Toxicological Research (Lapetox), University of Sorocaba, UNISO, Sorocaba, SP, Brazil
Bianca Carvalho Gentil
Laboratory of Toxicological Research (Lapetox), University of Sorocaba, UNISO, Sorocaba, SP, Brazil
Erika Leão Ajala Caetano
Post Graduate Program in Pharmaceutical Sciences, Department of Development and Evaluation of Bioactive Substances, University of Sorocaba, SP, Brazil; Laboratory of Toxicological Research (Lapetox), University of Sorocaba, UNISO, Sorocaba, SP, Brazil
Lucas Silva Rodrigues
Laboratory of Toxicological Research (Lapetox), University of Sorocaba, UNISO, Sorocaba, SP, Brazil
Leticia Favara Laurino
Post Graduate Program in Pharmaceutical Sciences, Department of Development and Evaluation of Bioactive Substances, University of Sorocaba, SP, Brazil; Laboratory of Toxicological Research (Lapetox), University of Sorocaba, UNISO, Sorocaba, SP, Brazil
Sara Rosicler Vieira Spim
Post Graduate Program in Pharmaceutical Sciences, Department of Development and Evaluation of Bioactive Substances, University of Sorocaba, SP, Brazil; Laboratory of Toxicological Research (Lapetox), University of Sorocaba, UNISO, Sorocaba, SP, Brazil
Angela Faustino Jozala
Laboratory of Toxicological Research (Lapetox), University of Sorocaba, UNISO, Sorocaba, SP, Brazil; Department of Technological and Environmental Processes, University of Sorocaba, UNISO, Sorocaba, SP, Brazil
Carolina Alves dos Santos
Post Graduate Program in Pharmaceutical Sciences, Department of Development and Evaluation of Bioactive Substances, University of Sorocaba, SP, Brazil
Denise Grotto
University of Sorocaba
Marli Gerenutti
Post Graduate Program in Pharmaceutical Sciences, Department of Development and Evaluation of Bioactive Substances, University of Sorocaba, SP, Brazil; Laboratory of Toxicological Research (Lapetox), University of Sorocaba, UNISO, Sorocaba, SP, Brazil; Department of Technological and Environmental Processes, University of Sorocaba, UNISO, Sorocaba, SP, Brazil

Краткое описание

This study evaluated the protective effect of Lentinus edodes in rats with streptozotocin-induced gestational diabetes mellitus (STZ-GDM) when administered orally. The rats received from the 1st to the 19th day of gestation daily doses of 100 or 200 mg/kg of lyophilized and reconstituted L. edodes; the animals in the saline control group and diabetic control group received a saline solution (DS). Gestational diabetes mellitus was induced by streptozotocin (80 mg/kg, administered intraperitoneally) on the fourth day of pregnancy; blood glucose > 180 mg/dL was considered to indicate STZ-GDM. L. edodes reduced catalase in plasma. We also observed reduced glucose in plasma, urea, triglycerides, and aspartate aminotransferase. There was a decrease in preimplantation loss when compared with the DS group. The doses of L. edodes used here had a protective effect on the preimplantation parameters in STZGDM. However, the mushroom was not able to reverse the deleterious effects caused by streptozotocin throughout the evolution of pregnancy.


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