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International Journal of Medicinal Mushrooms
Импакт фактор: 1.423 5-летний Импакт фактор: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN Печать: 1521-9437
ISSN Онлайн: 1940-4344

Выпуски:
Том 21, 2019 Том 20, 2018 Том 19, 2017 Том 18, 2016 Том 17, 2015 Том 16, 2014 Том 15, 2013 Том 14, 2012 Том 13, 2011 Том 12, 2010 Том 11, 2009 Том 10, 2008 Том 9, 2007 Том 8, 2006 Том 7, 2005 Том 6, 2004 Том 5, 2003 Том 4, 2002 Том 3, 2001 Том 2, 2000 Том 1, 1999

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.v18.i8.20
pages 661-669

Hepatoprotective Effect of Tricholoma giganteum (Agaricomycetes) in a Nonalcoholic Fatty Liver Disease Rat Model

Ramar Govindaraj
Division of Ethnopharmacology, Entomology Research Institute, Loyola College, Nungambakkam, Chennai, Tamil Nadu, India
Michael Gabriel Paulraj
Entomology Research Institute, Loyola College, Chennai 600 034, Tamil Nadu, India
Erenius Toppo
Division of Ethnopharmacology, Entomology Research Institute, Loyola College, Nungambakkam, Chennai, Tamil Nadu, India
Perumal Pandikumar
Division of Ethnopharmacology, Entomology Research Institute, Loyola College, Nungambakkam, Chennai, Tamil Nadu, India
Savarimuthu Ignacimuthu
Entomology Research Institute, Loyola College, Chennai 600 034, Tamil Nadu, India; International Scientific Partnership, College of Science, King Saud University, Riyadh, Saudi Arabia
Naif Abdhullah Al-Dhabi
Department of Botany and Microbiology, College of Sciences, King Saud University, Riyadh, Saudi Arabia

Краткое описание

Different concentrations of standardized ethanolic extract from the basidiocarps of Tricholoma giganteum Massee (TgEtOH) were screened for hepatoprotective effects in an animal model of rats with nonalcoholic fatty liver disease (NAFLD) fed a high-fat and high-fructose diet. After 4 weeks of treatment with TgEtOH, the relative liver weights, serum lipid concentrations, and biochemical profiles were found to be normal in treated animals compared with those given a standard drug. The macroscopic and histopathological studies clearly indicated that 200 mg/kg of ethanolic extract was effective in ameliorating the abnormalities of NAFLD. The findings indicate the efficacy of T. giganteum extract in liver protection. Future experiments on bioassay tailored fractionation of TgEtOH and mechanistic-based evaluation are required to assess the potential application of this mushroom as a food supplement in NAFLD.


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