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International Journal of Medicinal Mushrooms
Импакт фактор: 1.423 5-летний Импакт фактор: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN Печать: 1521-9437
ISSN Онлайн: 1940-4344

Выпуски:
Том 21, 2019 Том 20, 2018 Том 19, 2017 Том 18, 2016 Том 17, 2015 Том 16, 2014 Том 15, 2013 Том 14, 2012 Том 13, 2011 Том 12, 2010 Том 11, 2009 Том 10, 2008 Том 9, 2007 Том 8, 2006 Том 7, 2005 Том 6, 2004 Том 5, 2003 Том 4, 2002 Том 3, 2001 Том 2, 2000 Том 1, 1999

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.v18.i8.10
pages 651-660

Recent Advances and Challenges in Studies of Control of Cancer Stem Cells and the Gut Microbiome by the Trametes-Derived Polysaccharopeptide PSP (Review)

Joseph M. Wu
Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY
Barbara B. Doonan
Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY
Tze-chen Hsieh
Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY
Qingyao Yang
Institute of Microbiology and Immunology, Shanghai Normal University, Shanghai, People's Republic of China
Xiao-Tong Yang
Institute of Microbiology and Immunology, Shanghai Normal University; and Department of Pathology, the University of Hong Kong, R.P. China
Ming-Tat Ling
Laboratory of Cancer Therapeutic Development, Australian Prostate Cancer Research Centre, Queensland University of Technology, Queensland, Australia

Краткое описание

The medicinal mushroom Trametes versicolor has been well recognized for its activity in maintaining the general health of the population and in managing and treating human diseases in various cultures. Its use has been recently gaining acceptance and popularity in Western countries. The reported health benefits of T. versicolor led to a search for the identity of its bioactive ingredients. These efforts have resulted in the isolation of the polysaccharopeptide PSP from cultured mycelia of strain Cov-1, which expresses large amounts of PSP. The availability of highly purified PSP was followed by studies of its biological activities using tissue culture models and limited human clinical trials. In this review we summarize recent advances in the antitumorigenic and immunomodulatory effects of PSP, elimination of prostate cancer stem cells and control of the intestinal microbiome, and its interplay with host cells as a prebiotic. These findings may have implications for widening and repurposing the use of PSP


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