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ISSN Печать: 1521-9437
ISSN Онлайн: 1940-4344
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Anticancer Effects of Fraction Isolated from Fruiting Bodies of Chaga Medicinal Mushroom, Inonotus obliquus (Pers.:Fr.) Pilát (Aphyllophoromycetideae): In Vitro Studies
Краткое описание
The medicinal mushroom Chaga, Inonotus obliquus (Pers.:Fr.) Pilát (Hymenochaetaceae), has been used in folk medicine in Russia, Poland, and most of the Baltic countries, as a cleansing and disinfecting measure, and as decoctions for stomach diseases, intestinal worms, liver and heart ailments, and cancer treatment. Many reports have been published concerning the health promoting functions of this mushroom, including antibacterial, hepatoprotective, anti-inflammatory, antitumor, and antioxidant activities. The purpose of the present study was evaluation of in vitro anticancer activity of fraction IO4 isolated from I. obliquus. The effect on cell proliferation, motility and viability was assessed in a range of cancer and normal cells. Chaga fraction prepared from dried fruiting bodies was subjected to anticancer evaluation in human lung carcinoma (A549), colon adenocarcinoma (HT-29), and rat glioma (C6) cell cultures. Human skin fibroblasts (HSF), bovine aorta endothelial cells (BAEC), models of rat oligodendrocytes (OLN-93), hepatocytes (Fao), rat astroglia, and mouse neurons (P19) were applied to test toxicity in normal cells. The following methods were applied: tumor cell proliferation (MTT assay and BrdU assay), cytotoxicity (LDH assay), tumor cell motility (wound assay), tumor cell morphology (May-Grünwald-Giemsa staining), and death detection (ELISA). Chaga fraction elicited anticancer effects which were attributed to decreased tumor cell proliferation, motility and morphological changes induction. Of note is the fact that it produced no or low toxicity in tested normal cells. The data presented could open interesting paths for further investigations of fraction IO4 as a potential anticancer agent.
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De Silva Dilani D., Rapior Sylvie, Sudarman Enge, Stadler Marc, Xu Jianchu, Aisyah Alias S., Hyde Kevin D., Bioactive metabolites from macrofungi: ethnopharmacology, biological activities and chemistry, Fungal Diversity, 62, 1, 2013. Crossref
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Sak Katrin, Jürisoo Kadi, Raal Ain, Estonian folk traditional experiences on natural anticancer remedies: From past to the future, Pharmaceutical Biology, 52, 7, 2014. Crossref
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Patel Seema, Rauf Abdur, Khan Haroon, The relevance of folkloric usage of plant galls as medicines: Finding the scientific rationale, Biomedicine & Pharmacotherapy, 97, 2018. Crossref
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Patel Seema, Chaga (Inonotus Obliquus) Mushroom: Nutraceutical Assesement Based on Latest Findings, in Emerging Bioresources with Nutraceutical and Pharmaceutical Prospects, 2015. Crossref
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Schwartz Betty, Hadar Yitzhak, Sliva Daniel, The Use of Edible Mushroom Water Soluble Polysaccharides in the Treatment and Prevention of Chronic Diseases: A Mechanistic Approach, in Antitumor Potential and other Emerging Medicinal Properties of Natural Compounds, 2013. Crossref
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Navrátilová Zdeňka, Inonotus obliquuus - active compounds and therapeutic effects, Praktické lékárenství, 12, 6, 2016. Crossref
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Hapuarachchi K. K., Wen T. C., Therapeutic Potential of Medicinal Mushrooms: Insights into Its Use Against Covid-19, in Biology, Cultivation and Applications of Mushrooms, 2022. Crossref
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Panda Mrunmaya K., Paul Manish, Singdevsachan Sameer K., Tayung Kumananda, Das Swagat K., Thatoi Hrudayanath, Promising Anti-cancer Therapeutics From Mushrooms: Current Findings and Future Perceptions, Current Pharmaceutical Biotechnology, 22, 9, 2021. Crossref
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