Выходит 12 номеров в год
ISSN Печать: 1521-9437
ISSN Онлайн: 1940-4344
IF:
1.2
5-Year IF:
1.4
Immediacy Index:
0.3
Eigenfactor:
0.00066
JCI:
0.34
SJR:
0.274
SNIP:
0.41
CiteScore™::
2.8
H-Index:
37
Indexed in
Immunomodulatory Activities of Polysaccharides from White Button Mushroom, Agaricus bisporus (Agaricomycetes), Fruiting Bodies and Cultured Mycelia in Healthy and Immunosuppressed Mice
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Краткое описание
Agaricus bisporus is a very important edible and medicinal mushroom. In this study, we systematically investigated the monosaccharide composition, methylation, and immunomodulatory activities of polysaccharides from A. bisporus fruiting bodies (FPS), cultured mycelia (IPS), and fermentation broth (EPS). The results indicated that FPS was mainly composed of mannose; IPS, of glucose; and EPS, of galactose. However, the methylation results indicated that FPS, IPS, and EPS possessed different polysaccharide structures. Furthermore, FPS, IPS, and EPS caused remarkable increases in the thymus and spleen indexes; in the amounts of serum cytokines containing interleukin (IL)-2, IL-4, tumor necrosis factor-α (TNF-α), and interferon-γ (IFN-γ); in the counts of CD3+CD4+ lymphocytes and the ratio of CD4+ to CD8+ T lymphocytes; however, they decreased the counts of CD3+CD8+ lymphocytes in normal mice. Finally, in cyclophosphamide-treated mice, the FPS, IPS, and EPS were able to significantly restore the thymus and spleen indexes, lymphocyte proliferation, phagocytotic activity of peritoneal macrophages, and levels of IL-2, IL-6, IL-10, IL-17, TNF-α, and immunoglobin G. These findings suggest that FPS, IPS, and EPS could all be exploited as immunomodulatory agents and potential immunotherapeutic medicines for patients with inadequate immune function.
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Feng Yuqin, Zhang Jixian, Wen Chaoting, Sedem Dzah Courage, Chidimma Juliet Igbokwe, Duan Yuqing, Zhang Haihui, Recent advances in Agaricus bisporus polysaccharides: Extraction, purification, physicochemical characterization and bioactivities, Process Biochemistry, 94, 2020. Crossref
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Zhang Wen-Na, Gong Li-Li, Liu Yu, Zhou Zhong-Bo, Wan Chuan-Xing, Xu Jia-Jia, Wu Qing-Xi, Chen Lei, Lu Yong-Ming, Chen Yan, Immunoenhancement effect of crude polysaccharides of Helvella leucopus on cyclophosphamide-induced immunosuppressive mice, Journal of Functional Foods, 69, 2020. Crossref
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Liu Guo, Ye Jing, Li Wei, Zhang Jun, Wang Qun, Zhu Xiao-ai, Miao Jian-yin, Huang Ya-hui, Chen Yun-jiao, Cao Yong, Extraction, structural characterization, and immunobiological activity of ABP Ia polysaccharide from Agaricus bisporus, International Journal of Biological Macromolecules, 162, 2020. Crossref
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Xiang Xuelian, Cao Nan, Chen Feiyue, Qian Long, Wang Yifei, Huang Yunmao, Tian Yunbo, Xu Danning, Li Wanyan, Polysaccharide of Atractylodes macrocephala Koidz (PAMK) Alleviates Cyclophosphamide-induced Immunosuppression in Mice by Upregulating CD28/IP3R/PLCγ-1/AP-1/NFAT Signal Pathway, Frontiers in Pharmacology, 11, 2020. Crossref
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Zhao Xiaotong, Hou Peilin, Xin Huijie, Zhang Yanqing, Zhou Aimin, Lai Changjiangsheng, Xie Junbo, A glucogalactomanan polysaccharide isolated from Agaricus bisporus causes an inflammatory response via the ERK/MAPK and IκB/NFκB pathways in macrophages, International Journal of Biological Macromolecules, 151, 2020. Crossref
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Berger Ralf G., Bordewick Sven, Krahe Nina-Katharina, Ersoy Franziska, Mycelium vs. Fruiting Bodies of Edible Fungi—A Comparison of Metabolites, Microorganisms, 10, 7, 2022. Crossref