Выходит 12 номеров в год
ISSN Печать: 1521-9437
ISSN Онлайн: 1940-4344
Indexed in
Pharmacokinetic Studies of Ganoderic Acids from the Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), by LC-MS/MS
Краткое описание
Ganoderma lucidum is a famous medicinal mushroom that has been widely used in clinical practice and as a dietary supplementa. The triterpenoid ganoderic acids are the main constituents of G. lucidum. To determine the pharmacokinetic characteristics of ganoderic acids, we developed and validated a sensitive and selective liquid chromatography–tandem mass spectrometry method to determine simultaneously the concentration of 4 representative ganoderic acids in rat plasma after oral administration of the extract from G. lucidum. Because of the similarity of their chemical structures, the 4 components exhibited similar pharmacokinetic behaviors in some aspects. However, some of the pharmacokinetic parameters and the reabsorption peaks in the plasma concentration–time curves of ganoderic acids B and E after oral administration of the extract were different from those of ganoderic acids D and A because of the metabolic transformation among the ganoderic acids. These results increase our knowledge about the use of G. lucidum.
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Wong Ho-Yi, Wong Melody Yee-Man, Hu Bin, So Pui-Kin, Chan Chi-On, Mok Daniel Kam-Wah, Yao Zhong-Ping, Rapid differentiation of Ganoderma species by direct ionization mass spectrometry, Analytica Chimica Acta, 999, 2018. Crossref
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Cao Fang-Rui, Xiao Bing-Xin, Wang Li-Sha, Tao Xue, Yan Ming-Zhu, Pan Rui-Le, Liao Yong-Hong, Liu Xin-Min, Chang Qi, Plasma and brain pharmacokinetics of ganoderic acid A in rats determined by a developed UFLC–MS/MS method, Journal of Chromatography B, 1052, 2017. Crossref
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Li Changqin, Cui Yiping, Lu Jie, Liu Cunyu, Chen Sitan, Ma Changyang, Liu Zhenhua, Wang Jinmei, Kang Wenyi, Ionic Liquid-Based Ultrasonic-Assisted Extraction Coupled with HPLC and Artificial Neural Network Analysis for Ganoderma lucidum, Molecules, 25, 6, 2020. Crossref
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Adotey Gideon, Alolga Raphael N., Quarcoo Abraham, Gedel Mohammed Ahmed, Anang Abraham K., Holliday John C., Ultra Performance Liquid Chromatography-Quadrupole Time-of-Flight Mass Spectrometry (UPLC-Q-TOF-MS)-based metabolomic analysis of mycelial biomass of three Ganoderma isolates from the Lower Volta River Basin of Ghana, Journal of Pharmaceutical and Biomedical Analysis, 205, 2021. Crossref
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Li Changqin, Cui Yiping, Lu Jie, Meng Lijun, Ma Changyang, Liu Zhenhua, Zhang Yan, Kang Wenyi, Spectrum-effect relationship of immunologic activity of Ganoderma lucidum by UPLC-MS/MS and component knock-out method, Food Science and Human Wellness, 10, 3, 2021. Crossref
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Liu Hong, Liu Honggao, Li Jieqing, Wang Yuanzhong, Review of Recent Modern Analytical Technology Combined with Chemometrics Approach Researches on Mushroom Discrimination and Evaluation, Critical Reviews in Analytical Chemistry, 2022. Crossref