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International Journal of Medicinal Mushrooms
Импакт фактор: 1.423 5-летний Импакт фактор: 1.525 SJR: 0.431 SNIP: 0.716 CiteScore™: 2.6

ISSN Печать: 1521-9437
ISSN Онлайн: 1940-4344

Выпуски:
Том 22, 2020 Том 21, 2019 Том 20, 2018 Том 19, 2017 Том 18, 2016 Том 17, 2015 Том 16, 2014 Том 15, 2013 Том 14, 2012 Том 13, 2011 Том 12, 2010 Том 11, 2009 Том 10, 2008 Том 9, 2007 Том 8, 2006 Том 7, 2005 Том 6, 2004 Том 5, 2003 Том 4, 2002 Том 3, 2001 Том 2, 2000 Том 1, 1999

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v14.i5.30
pages 459-466

Antimalarial and Hepatoprotective Effects of Crude Ethanolic Extract of Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (W.Curt.:Fr.)P.Karst. (Higher Basidiomycetes), in Plasmodium berghei-Infected Mice

Olarewaju M. Oluba
Department of Chemical Sciences, College of Natural Sciences, Joseph Ayo Babalola University, Ikeji-Arakeji, Osun State, Nigeria; Department of Biochemistry, Faculty of Life Sciences, University of Benin, Benin City, Nigeria
Augustine O. Olusola
Department of Biochemistry, Faculty of Science, Adekunle Ajasin University, Akungba Akoko, Nigeria
Bamidele S. Fagbohunka
Department of Chemical Sciences, College of Natural Sciences, Joseph Ayo Babalola University, Ikeji-Arakeji, Osun State, Nigeria
E. Chukwu Onyeneke
Department of Biochemistry, Faculty of Life Sciences, University of Benin, Benin-City, Nigeria

Краткое описание

This study was aimed at investigating the in vivo antimalarial activity (using some biochemical indices) of crude aqueous extracts of the fruiting bodies of Ganoderma lucidum, a mushroom with well-established medicinal properties. A rodent malaria parasite, Plasmodium berghei (1 × 107), was inoculated intraperitoneally into Swiss albino mice. The test groups were administered G. lucidum extract and chloroquine (CQ, as standard drug), while the control groups were administered the same amount of distilled water by an intragastric tube once daily. The antimalarial activity of the extract was investigated from the suppressive, curative, and prophylactic effects of the extract on parasite growth. Serum aminotransferases (AST and ALT), alkaline phosphatase (ALP), and gamma glutamine transpeptidase (γ-GT) levels monitored following the 4-day suppressive test were significantly reduced, with a corresponding significant increase in the livers of mice treated with the extract compared with infected untreated mice. The results obtained from this study provide scientific justification in an animal model of malaria that an ethanolic extract of G. lucidum possesses potent antimalarial activity and also could help ameliorate the attendant Plasmodium-induced liver damage due to malarial infection.


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