Доступ предоставлен для: Guest
Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции
International Journal of Physiology and Pathophysiology
SJR: 0.116

ISSN Печать: 2155-014X
ISSN Онлайн: 2155-0158

Archives: Volume 1, 2010 to Volume 9, 2018

International Journal of Physiology and Pathophysiology

DOI: 10.1615/IntJPhysPathophys.v9.i2.80
pages 161-168

Effect of Magnetic Field on Blood Oxygen Transport Function during a Hydrogen Sulfide Donor Introduction

Victor V. Zinchuk
Grodno State Medical University, Grodno, Belarus
Vladimir O. Lepeev
Grodno State Medical University, Grodno, Belarus

Краткое описание

Gas transmitters (hydrogen sulfide, H2S, nitric oxide, NO) belong to gaseous signaling compounds, which are important for transduction of physiological signals. However, contribution of hydrogen sulfide to effects of magnetic field (MF) on oxygen transport function is still poorly understood. So, the effect of magnetic field on oxygen transport function of the blood upon the administration of a hydrogen sulfide donor was evaluated in the work. The tail artery of outbred white male rats was exposed to MF, and the drugs affecting hydrogen sulfide formation, namely, sodium hydrosulfide (NaHS); L-arginine; NG -nitro-L-arginine methyl ester (L-NAME), a nonselective inhibitor of NO synthase; and DL-propargylglycine (PAG), an irreversible inhibitor of cystathionine-γ-lyase were injected intraperitoneally for 10 days. Oxygen transport function of the blood, the contents of hydrogen sulfide and nitrate/nitrite anions (NO2 /NO3) were determined in the blood plasma. It has been shown that an exposure of rats to MF and administration of either NaHS or amino acid L-arginine leads to a decrease in the affinity of hemoglobin for oxygen and is accompanied by an increase in the content of gas transmitters (NO and H2S) in the blood. With the introduction of L-NAME and PAG, the effect of MF on the affinity of hemoglobin for oxygen is not manifested. Thus, MF realizes its effect through the hydrogen sulfide and nitric oxide.


Articles with similar content:

Effects of Stimulation and Blockade of Endogenous Hydrogen Sulfide Synthesis in Myocardial Ischemia-Reperfusion
International Journal of Physiology and Pathophysiology, Vol.5, 2014, issue 3
Yulia V. Goshovska, Vadim F. Sagach, Tetyana V Shimanskaya, Raisa A. Dobrovolska
Hydrogen Sulfide Inhibits Calcium-Induced Mitohondrial Permeability Transition Pore Opening in the Heart of Adult and Old Rats
International Journal of Physiology and Pathophysiology, Vol.3, 2012, issue 2
Snizhana V. Chorna, Nataliya A. Strutynska, Galyna L. Vavilova, Vadim F. Sagach, Olena M. Semenykhina
Propargylglycine Restores Endothelium-Dependent Relaxation of Aortic Smooth Muscle in Old Rats
International Journal of Physiology and Pathophysiology, Vol.6, 2015, issue 3
Lyubov G. Stepanenko, Konstantin O. Drachuk, Olga V. Bazilyuk, Vadim F. Sagach, Anatoliy V. Kotsuruba
Age-Associated Mitochondrial Dysfunction in the Heart Accompanied by Constitutive NO-Synthases Uncoupling on the Background of Oxidative and Nitrosative Stress
International Journal of Physiology and Pathophysiology, Vol.8, 2017, issue 2
Nataliya A. Strutynska, Lidiya A. Mys, Alina Yu. Budko, Vadim F. Sagach, Anatoliy V. Kotsuruba
Hydrogen Sulfide Inhibits Calcium-Induced Mitochondrial Permeability Transition Pore Opening in the Heart of Spontaneously Hypertensive Rats
International Journal of Physiology and Pathophysiology, Vol.4, 2013, issue 4
Nataliya A. Strutynska, Galyna L. Vavilova, Vadim F. Sagach, Nataliya A. Dorofeyeva