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Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции
International Journal of Physiology and Pathophysiology
SJR: 0.116

ISSN Печать: 2155-014X
ISSN Онлайн: 2155-0158

Archives: Volume 1, 2010 to Volume 9, 2018

International Journal of Physiology and Pathophysiology

DOI: 10.1615/IntJPhysPathophys.v9.i2.100
pages 181-193

Epigenetics of Arterial Hypertension

Mykola V. Khaitovych
Bogomolets National Medical University, Kyiv, Ukraine
Anatoliy P. Burlaka
Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine
Viktoriia S. Potaskalova
Bogomolets National Medical University, Kyiv, Ukraine

Краткое описание

The literature review summarizes current data on the role of epigenetic effects (DNA methylation, post-translational modification of histones, RNA interference) in the mechanisms of primary arterial hypertension development. The contribution of oxidative stress to violation of transcriptional and epigenetic regulation in hypertension has been pointed out, as well as the role of hyperhomocysteinemia (homocysteine is an epigenetic by-product of protein DNA/RNA methylation) in the formation of vascular stiffness. Mechanisms of regulation of cytoprotective function of autophagy are considered. On the basis of epigenetic effects, the following prospects are promising: 1) prevention and treatment of hypertension with the use of resveratrol (it activates SIRT1, reduces oxidative stress, and increases the activity of endothelial NO synthase); folates (they prevent the hypomethylation of DNA); probiotics (affecting the microRNA); melatonin (it reduces dimethylation of the endothelial NO synthase promoter); 2) prevention of disease progression by the use of inhibitors of DNA methylation and autophagy modulators to reduce fibrosis and myocardial hypertrophy.

Ключевые слова: epigenetics, arterial hypertension

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