Доступ предоставлен для: Guest
Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции
International Journal of Physiology and Pathophysiology
SJR: 0.116

ISSN Печать: 2155-014X
ISSN Онлайн: 2155-0158

Archives: Volume 1, 2010 to Volume 9, 2018

International Journal of Physiology and Pathophysiology

DOI: 10.1615/IntJPhysPathophys.v9.i2.60
pages 143-151

Efficiency of Bisphosphonic Acids in Female Rats with Experimental Osteoporosis

Vladyslav V. Povoroznyuk
Chebotarev Institute of Gerontology, National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine, Ukrainian Scientific-Medical Center of Osteoporosis, Kyiv, Ukraine
Vasyl I. Pekhnyo
Vernadsky Institute of general and inorganic chemistry, National Academy of Sciences of Ukraine, Kyiv, Ukraine
Nataliia V. Grygorieva
Chebotarev Institute of Gerontology, National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine, Ukrainian Scientific-Medical Center of Osteoporosis, Kyiv, Ukraine
Olexandra M. Kozachkova
Vernadsky Institute of general and inorganic chemistry, National Academy of Sciences of Ukraine, Kyiv, Ukraine
Nataliia V. Tsaryk
Vernadsky Institute of general and inorganic chemistry, National Academy of Sciences of Ukraine, Kyiv, Ukraine

Краткое описание

We evaluated the efficiency of different bisphosphonic acids, including ethylidenebisphosphonic (EBP), aminoethylidenebisphosphonic (AEBP), 1-phenyl-1-hydroxymethylenebisphosphonic (PhHMBP), and 1 -phenyl- 1-fluoro- methylenebisphosphonic (PhFMBP) acids on the bone mineral density and bone mineral content in female rats with experimental osteoporosis, compared to zoledronic acid in combination with calcium and vitamin D supplementation. The results indicate the absence of significant changes in bone mineral density indexes in female rats after bilateral ovariectomy, treated with EBF, AEBF, and PhHMBP in combination with calcium and vitamin D supplements. Significant dynamics of bone mineral density of total skeleton [from (0.100 ± 0.007) to (0.105 ± 0.008) g/cm2 after 3 months] in the rats treated with combined PhFMBP, calcium, and vitamin D administration requires further exploration of PhFMBP effectiveness in prevention and treatment of systemic osteoporosis.


Articles with similar content:

The Anabolic Effects of Vitamin D-Binding Protein- Macrophage Activating Factor (DBP-MAF) and a Novel Small Peptide on Bone
Critical Reviews™ in Eukaryotic Gene Expression, Vol.13, 2003, issue 2-4
Kristina J. Grecco, Gary B. Schneider, Steven N. Popoff, Fayez F. Safadi
Kirenol Exhibits the Protective Role against N-Methyl-N-Nitrosourea-Induced Gastric Cancer in Rats via Modulating the Oxidative Stress and Inflammatory Markers
Journal of Environmental Pathology, Toxicology and Oncology, Vol.39, 2020, issue 4
Yuzhu Li, Weiwei Liu, Chengzhen Li
The Assessment of Gadolinium Orthovanadate Nanoparticles Value for Neonatally-Induced Reproductive Disease in Male Rats
International Journal of Physiology and Pathophysiology, Vol.8, 2017, issue 4
Vladimir K. Klochkov, Yury I. Karachentsev, Natalia P. Smolenko, Elina E. Chistyakova, Inna O. Belkina, Nina A. Karpenko, Yury V. Malukin
Protective Role of Naringenin Against Doxorubicin-Induced Cardiotoxicity in a Rat Model: Histopathology and mRNA Expression Profile Studies
Journal of Environmental Pathology, Toxicology and Oncology, Vol.33, 2014, issue 4
Kumaresan Ganesan, Murugesan Ramachandran, Swathika Subburaman
Protective Role of Perillic Acid Against Radiation−Induced Oxidative Stress, Cytokine Profile, DNA Damage, and Intestinal Toxicity in Mice
Journal of Environmental Pathology, Toxicology and Oncology, Vol.29, 2010, issue 3
P. Pratheeshkumar, Girija Kuttan, T.J. Raphael