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Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции
International Journal of Physiology and Pathophysiology
SJR: 0.116

ISSN Печать: 2155-014X
ISSN Онлайн: 2155-0158

Archives: Volume 1, 2010 to Volume 9, 2018

International Journal of Physiology and Pathophysiology

DOI: 10.1615/IntJPhysPathophys.v9.i2.40
pages 127-133

Impact of Experimental Chronic Social Stress on Biliary Bile Acid Content in Male Rats

A.M. Liashevych
Kyiv National Taras Shevchenko University, Ukraine
I.I. Tubalceva
Kyiv National Taras Shevchenko University, Ukraine
Yevdokiya M. Reshetnik
Kyiv National Taras Shevchenko University, Kyiv, Ukraine
Oleksandr V. Bondarenko
Taras Shevchenko National University, Kyiv, Ukraine
Stanislav P. Veselsky
Kyiv National Taras Shevchenko University, Kyiv, Ukraine
Mykola Yu. Makarchuk
Kyiv National Taras Shevchenko University, Kyiv, Ukraine

Краткое описание

The biliary bile acid composition was examined in male rats subjected to experimental chronic social stress. It has been found that the concentration of conjugated bile acids in rat bile was significantly lower in stressed animals compared to that in the control group. Taurocholic acid concentration in bile of stressed animals was lower than that in the control group by 23.4−23.6%. Biliary concentration of chenodeoxycholic and deoxycholic taurine conjugate in stressed animals was lower by 18.9−23.14%, compared to the control group. Biliary concentration of bile acids conjugated with glycine in stressed male rats was also lower than that in the control group. In particular, glycocholic acid content was lower by 32.9−51.3%, and the concentration of glycochenodeoxycholic and glycodeoxycholic acids was lower by 33.8−55.7%. However, biliary concentrations of chenodeoxycholic and deoxycholic acids in stressed animal's bile were higher than in control samples by 19.8−25%. The most pronounced difference in biliary bile acid content between the male rats subjected to chronic social stress and that in the control group of rats was the emergence of lithocholic and taurolithocholic acids in the hepatic secret of stressed animal. We suggest that in male rats subjected to chronic social stress, synthesis, biotransformation, and transport of bile acids into the bile are inhibited. The role of chronic social stress in disorders of bile formation and the role of bile acids as bioactive regulatory compounds in occurrence and progression of stress-induced pathologies require further research.

Ключевые слова: liver, bile, bile acid, chronic social stress

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