Доступ предоставлен для: Guest
International Journal of Physiology and Pathophysiology
Главный редактор: Vadim F. Sagach (open in a new tab)

Выходит 4 номеров в год

ISSN Печать: 2155-014X

ISSN Онлайн: 2155-0158

SJR: 0.116

Calcium Signals Induced by Tonic Firing in the Rat Retinal Ganglion Cells

Том 2, Выпуск 4, 2011, pp. 303-308
DOI: 10.1615/IntJPhysPathophys.v2.i4.10
Get accessGet access

Краткое описание

On rat retinal preparation in whole-cell mode retinal ganglion cells (RGC) tonic firing induced calcium signals were recorded and their modulation by Kv3 potassium channels was studied. RGC depolarization with 500 ms current steps caused tonic action potentials (AP) generation and development of calcium signals which amplitude depended quite linearly on mean AP frequency with mean slope (1.4 ± 0.2) s·nmol/l (n = 5). The calcium signals mean tau of decay value was (6.8 ± 1.4) s (n = 5). After application of tetraethylammoniun (500 μM), which in such a concentration blocks Kv3.1/Kv3.2 potassium channels, decreasing of firing frequency, increasing of AP width and decreasing of fast afterhyperpolarization amplitude were observed. In the blocker presence the calcium signal amplitude vs mean AP frequency dependency slope mean value increased to (2.1 ± 0.3) s·nmol/l. The calcium signals decay not changed significantly, the mean value was (8.9 ± 1.6) s (n = 5). Thus, voltage-dependent Kv3.1/Kv3.2 potassium channels, which play a key role in tonic firing pattern generation in RGC, also modulate appropriate calcium signals and prevent the cells from significant intracellular calcium increasing and its possible cytotoxic action.

ЦИТИРОВАНО В
  1. MARTYNIUK N.Ya., MASLOV V.Yu, PURNYN H.E., FEDULOVA S.A., VESELOVSKY N.S., Changes of ongoing activity and electrophysiological characteristics of the rat retinal ganglion cells at diabetes mellitus, Fiziolohichnyĭ zhurnal, 64, 1, 2018. Crossref

387 Просмотры статей 3 Загрузка статей Метрики
387 ПРОСМОТРЫ 3 ЗАГРУЗКИ 1 Crossref ЦИТАТЫ Google
Scholar
ЦИТАТЫ

Статьи с похожим содержанием:

Calcium Signals Induced By Tonic Firing In Rat Retinal Ganglion Cells International Journal of Physiology and Pathophysiology, Vol.3, 2012, issue 1
Vitally Y. Maslov, Mycola S. Veselovsky, Kyryl I. Kuznetsov, Svetlana A. Fedulova
Modulating Effect of Peptide Semax on the Level of Synaptic Activity and Short-Term Plasticity in Glutamatergic Synapses of Co-Cultured Dorsal Root Ganglion and Dorsal Horn Neurons of Rats International Journal of Physiology and Pathophysiology, Vol.7, 2016, issue 3
Mariia S. Shypshyna , Mycola S. Veselovsky, Nikolai F. Myasoedov, Stanislav I. Shram, Svetlana A. Fedulova
Nonuniform Distribution and Contribution of P- and P/Q-Types Calcium Channels to Short-Term Inhibitory Synaptic Plasticity in Cultured Hippocampal Neurons International Journal of Physiology and Pathophysiology, Vol.2, 2011, issue 3
Oksana P. Kolesnyk-Mizerna, Mycola S. Veselovsky, Svetlana A. Fedulova
Changes in Calcium-Dependent Potassium Conductance of Isolated Smooth Muscle Cells of the Rat Bladder in Experimental Diabetes International Journal of Physiology and Pathophysiology, Vol.3, 2012, issue 1
Oksana M. Paduraru, Dmytro A. Kryshtal, Oleg Yu. Kit, Oleksiy I. Boldyriev, Yaroslav M. Shuba, Volodymyr V. Rekalov
Electrical Properties of Retinal Ganglion Cells of the Rats with Streptozotocin-Induced Diabetes Mellitus International Journal of Physiology and Pathophysiology, Vol.5, 2014, issue 1
Nataliya N. Veselovskaya, Vitally Y. Maslov, Mycola S. Veselovsky, Kyryl I. Kuznetsov, Svetlana A. Fedulova

Последний выпуск

Systemic Toxic Dental Sealant-Induced Effect on Nervous Tissue in vitro O. A. Znachkova, Irina V. Lushnikova, Galina G. Skibo, M. Y. Antonenko, Nana V. Voitenko Impact of Various Polyphenols on Disturbance of Cholesterol Metabolism under Insulin Resistance V. P. Fylymonenko, A. L. Zagayko Target Correction of Mitochondrial Dysfunction in Parkinson's Disease by Capicor Iryna M. Mankovska, Kateryna V. Rosova, Olga O. Gonchar, Valentina I. Nosar, Larisa. V. Bratus, Tetyana I. Drevitska, Ivan D. Glazyrin, Nina V. Karasevich, Iryna M. Karaban Changes in Ongoing Activity and Electrophysiological Characteristics of the Rat Retinal Ganglion Cells in Diabetes Mellitus N. Ya. Martyniuk, V. Yu. Maslov, Helen E. Purnyn, Svetlana A. Fedulova, Nikolai S. Veselovsky Sex Characteristics of Hydrogen Sulfide Effect on Ischemia-Reperfusion in Rat Myocardium Andrii V. Melnyk, Nataliia V. Zaichko, Oleksii A. Khodakovskyi, Olga V. Khodakivska Cardiohemodynamic Changes in Focal Cerebral Ischemia Roman R. Sharipov, Nataliya A. Dorofeyeva, Vadim F. Sagach Cerebral Hemodynamics and Electroencephalographic Pattern in Patients with Symptomatic Epilepsy at Combined Treatment with Transcranial Direct Current Stimulation Kateryna V. Yatsenko Physiological Endurance of Skeletal Muscle Increases under C60 Fullerene Application before Physical Load Tetyana Yu. Matvienko, Danylo Zavodovskiy, Iryna V. Mishchenko, Kateryna I. Bogutska, Yuriy I. Prylutskyy, Sofia Paradizova, Larisa Bezuh, Uwe Ritter, Peter Scharff Possible Mechanisms Underlying Association between Thyroiditis and Thyroid Papillary Carcinoma Tamara M. Myshunina, Mykola D. Tronko Index, Volume 9, 2018
Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции Цены и условия подписки Begell House Контакты Language English 中文 Русский Português German French Spain