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Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции
International Journal of Physiology and Pathophysiology
SJR: 0.116

ISSN Печать: 2155-014X
ISSN Онлайн: 2155-0158

Archives: Volume 1, 2010 to Volume 9, 2018

International Journal of Physiology and Pathophysiology

DOI: 10.1615/IntJPhysPathophys.v2.i4.30
pages 321-325

Anaesthetic and Postanaesthetic Effect of Isoflurane on the Multiple-Unit Activity of the Immature Rat Hippocampus

Olena V. Isaeva
Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine
Dmytro S. Isaev
Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine

Краткое описание

We investigated anesthetic and postanaesthetic effect of isoflurane on the multi-unit activity (MUA) in the CA3 region of immature rat hippocampus. MUA amplitude did not significantly change during application of isoflurane. On the other hand MUA frequency significantly decreased during the anesthesia. After isoflurane discontinuation two phases of MUA frequency recovery were observed: initial rapid increase followed by a slower recovery to the control level. Comparison of recovering period of the receptor mediated systems and spontaneous field activity from isoflurane anesthesia is discussed.

Ключевые слова: isoflurane, multiple-unit activity, rat, hippocampus

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