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Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции
International Journal of Physiology and Pathophysiology
SJR: 0.116

ISSN Печать: 2155-014X
ISSN Онлайн: 2155-0158

Archives: Volume 1, 2010 to Volume 9, 2018

International Journal of Physiology and Pathophysiology

DOI: 10.1615/IntJPhysPathophys.v6.i1.40
pages 35-39

The Features of Sexual Behavior of Female Rats with Hyperandrogenia in Pubertal and Postpubertal Periods

Nadiya D. Nosenko
V.P.Komissarenko Institute of Endocrinology and Metabolism of National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine
Anna A. Lymareva
VP.Komissarenko Institute of Endocrinology and Metabolism of National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine;Zaporozhye State Medical Academy for Postgraduate Education, Zaporozhye, Ukraine

Краткое описание

The female and male types of sexual behavior was examined in 3- and 6-month old female rats which were exposed to an androgen excess (subcutaneous implantation of Silastic capsules containing 5 mg of crystalline testosterone) from the beginning of pubertal period (at the age of 35 days), or within postpubertal period (at the age of 4 months). Hyperandrogenia in pubertal period had no effect on female sexual behavior formation, but it led to the appearance of male behavior components in 100% of animals. In female rats which were implanted with testosterone capsules in postpubertal period, sexual disturbances were more pronounced and characterized by masculinization and defeminization, which was due to a higher degree of androgenic saturation. The data obtained suggest a leading role of hyperandrogenemia in the pathogenesis of sexual behavior disturbances in female rats in different periods of individual development.


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