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Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции
International Journal of Physiology and Pathophysiology
SJR: 0.116

ISSN Печать: 2155-014X
ISSN Онлайн: 2155-0158

Archives: Volume 1, 2010 to Volume 9, 2018

International Journal of Physiology and Pathophysiology

DOI: 10.1615/IntJPhysPathophys.v6.i1.80
pages 69-77

Effects of Dietary ω-3 Polyunsaturated Fatty Acids on Myocardial Mitochondria Functioning under Isopreterenol-induced Heart Damage

Olga S. Panasiuk
Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine
Angela M. Shysh
Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine
Oleksiy O. Moibenko
International Center for Astronomical and Medico-Biological Research, National academy of Sciences of Ukraine, Department of Experimental Cardiology, Department of General and Molecular Pathophysiology, Bogomoletz institute of Physiology, Kyiv, Ukraine

Краткое описание

We studied the effect of ω-3 polyunsaturated fatty acids (ω-3 PUFA, a drug Epadol, 0.1mg/100 g body weight for 4 weeks) on the functioning of the rat myocardium mitochondria under isopreterenol-induced injury (two subcutaneous injections of isopreterenol at the dose 60 mg/kg/day). It has been shown that isoproterenol-induced damage to the heart leads to respiratory failure in isolated mitochondria in the presence of succinate. An administration of ω-3 PUFAs significantly restores the respiration rate of the mitochondria: ADP-stimulated (V3) respiration rate increases by 70.1%, the rate of phosphorylation in a relatively steady state (V2) increases by 39.9%, and the respiratory control ratio − by 45.19% compared to rats injected subcutaneously with isoproterenol solution. In addition, the ability of ω-3 PUFAs to decrease mitochondrial swelling (by 60%) in nominally calcium free solution has been shown. The results obtained indicate that ω-3 PUFAs reduce mitochondrial dysfunction in the heart under isopreterenol-induced damage to the latter.


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