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Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции
International Journal of Physiology and Pathophysiology
SJR: 0.116

ISSN Печать: 2155-014X
ISSN Онлайн: 2155-0158

Archives: Volume 1, 2010 to Volume 9, 2018

International Journal of Physiology and Pathophysiology

DOI: 10.1615/IntJPhysPathophys.v1.i3.80
pages 267-276

The Effect of Lomg-Term Exercise Training on the Changes in the Functional State of Heart duringIschemia-Reperfusion, the Sensitivity of Calcium- Induced Mitochondrial Permeability Transition Pore and the Uncoupling Protein 3 Expression

Nataliya A. Strutynska
Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine
Snizhana V. Chorna
Bogomoletz Institute of Physiology, National Academy of Science of Ukraine, Kyiv
Sergiy O. Talanov
Bogomoletz Institute of Physiology of the National Academy of Sciences of Ukraine, Kyiv, Ukraine
Galyna L. Vavilova
Bogomoletz Institute of Physiology, National Academy of Science of Ukraine, Kyiv
N. M. Gaidai
Bogomoletz Institute of Physiology, National Academy of Science of Ukraine, Kyiv
Vadim F. Sagach
Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine

Краткое описание

The effect of long exercise training on the indexes of the functional state isolated by Lanhendorf rat hearts during ischemia-reperfusion, the sensitivity of calcium-induced NO-dependent mitochondrial permeability transition pore (MPTP) opening as well as the mitochondrial uncoupling protein 3 (UCP3) expression were investigated. The obtained results indicate the positive effect of long exercise training on the heart functional state. Reperfusion injurings of the heart contractile function and its myocardial oxygen metabolism were less pronounced in adapted to exercise loading rats (trained rats). It was shown that the sensitivity of mitochondrial permeability transition pore opening to its inductor Ca2+ in the trained rats heart decreased compared with control animals. Thus, in the trained rat heart mitochondria had a significant increase in cNOS activity (almost twice), slight increase in the iNOS activity compared with control, and a slight increase in the hydrogen peroxide level. Under adaptation to the long exercise training, the expression level of UCP3 in rat heart mitochondria was reduced by 65 % compared with the control. These results suggest that the decrease in the expression level of UCP3 in the adaptation of animals to exercise training may play the certain role in the complex mechanism of adaptive response of the heart, that may be aimed mainly on the efficiency of oxidative phosphorylation in mitochondria and, consequently, to increase in the ATP synthesis. Thus, long exercise training contributes to the improvement of the heart functional state, namely, its contractile function, and also increases the resistance to reperfusion injury, reducing the sensitivity of the MPTP opening to the action of calcium ions by increasing the activity of mitochondrial constitutive NOS and synthesis of nitric oxide, an endogenous inhibitor of MPTP opening.

Ключевые слова: ischemia-reperfusion, MPTP, UCP3

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