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ISSN Печать: 1045-4403
ISSN Онлайн: 2162-6502
Indexed in
Estrogen Receptor Action
Краткое описание
Today we have to consider the existence of two estrogen receptors, a and b, in our attempts to understand the role of estrogen receptors in physiology and pathology, and to explain the pharmacology of estrogens, antiestrogens, and SERMs. Both ERa and ERb belong to the large family of nuclear receptors that function as hormone-dependent transcription factors with important roles in the endocrine signaling system. Estrogen signaling is dependent on multiple mechanisms involving the two estrogen receptors and, perhaps, also other, non–estrogen receptor–related proteins. In the post-genomic era, with the help of technological advancements, we will see a dramatic increase in our understanding of the biological role of the two estrogen receptors, and in the function of estrogens, antiestrogens, and SERMs, which will significantly enhance our chances to develop designer drugs with dramatically improved therapeutic profiles.
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Hussain Imran, Bhan Arunoday, Ansari Khairul I., Deb Paromita, Bobzean Samara A.M., Perrotti Linda I., Mandal Subhrangsu S., Bisphenol-A induces expression of HOXC6, an estrogen-regulated homeobox-containing gene associated with breast cancer, Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 1849, 6, 2015. Crossref
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Deb Paromita, Bhan Arunoday, Hussain Imran, Ansari Khairul I., Bobzean Samara A., Pandita Tej K., Perrotti Linda I., Mandal Subhrangsu S., Endocrine disrupting chemical, bisphenol-A, induces breast cancer associated gene HOXB9 expression in vitro and in vivo, Gene, 590, 2, 2016. Crossref
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