Доступ предоставлен для: Guest
Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции
Critical Reviews™ in Eukaryotic Gene Expression
Импакт фактор: 2.156 5-летний Импакт фактор: 2.255 SJR: 0.649 SNIP: 0.599 CiteScore™: 3

ISSN Печать: 1045-4403
ISSN Онлайн: 2162-6502

Выпуски:
Том 30, 2020 Том 29, 2019 Том 28, 2018 Том 27, 2017 Том 26, 2016 Том 25, 2015 Том 24, 2014 Том 23, 2013 Том 22, 2012 Том 21, 2011 Том 20, 2010 Том 19, 2009 Том 18, 2008 Том 17, 2007 Том 16, 2006 Том 15, 2005 Том 14, 2004 Том 13, 2003 Том 12, 2002 Том 11, 2001 Том 10, 2000 Том 9, 1999 Том 8, 1998 Том 7, 1997 Том 6, 1996 Том 5, 1995 Том 4, 1994

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.v9.i3-4.190
pages 345-351

Functional Links between Nuclear Structure, Gene Expression, DNA Replication, and Methylation

Heinrich Leonhardt
Max Delbruck Center for Molecular Medicine, 13125 Berlin, Germany
Hans-Peter Rahn
Max Delbruck Center for Molecular Medicine, 13125 Berlin, Germany
M. Cristina Cardoso
Max Delbruck Center for Molecular Medicine, 13125 Berlin, Germany

Краткое описание

Over the last decades it became clear that mammalian nuclei are highly organized. Nuclear processes like DNA replication and RNA metabolism take place in distinct subnuclear foci, which are enriched for enzymes involved in the corresponding biochemical reactions. This colocalization of functions with their respective factors is often referred to as functional organization of the nucleus. This organization is achieved by assembly of different enzymes and regulatory factors into high-molecular-weight complexes that are tethered to insoluble nuclear structures. Recently, several links between nuclear structure, gene expression, DNA replication, and methylation have been described that illustrate the interrelation of higher-order structures and nuclear functions. New insights into the functional organization of the nucleus and how it could explain the high precision and overall coordination of nuclear processes are discussed.


Articles with similar content:

Nuclear Domains Involved in RNA Synthesis, RNA Processing, and Replication
Critical Reviews™ in Eukaryotic Gene Expression, Vol.6, 1996, issue 2-3
Luitzen de Jong, Karin A. Mattern, Marjolein A. Grande, Roel van Driel, Wouter Schul
Recent Advances in Chemokines and Chemokine Receptors
Critical Reviews™ in Immunology, Vol.19, 1999, issue 1
Joseph A. Hedrick, Albert Zlotnik, Janine Morales
Aberrant Receptor Signaling and Trafficking as Mechanisms in Oncogenesis
Critical Reviews™ in Oncogenesis, Vol.13, 2007, issue 1
Tor Erik Rusten, Kaisa Haglund, Harald Stenmark
Locostatin Disrupts Association of Raf Kinase Inhibitor Protein With Binding Proteins by Modifying a Conserved Histidine Residue in the Ligand-Binding Pocket
Forum on Immunopathological Diseases and Therapeutics, Vol.2, 2011, issue 1
Gabriel Fenteany, Christian E. Argueta, Jose A. Gascon, Lochana C. Menikarachchi, Anwar B. Beshir
The Dynamics of the Nucleolus
Critical Reviews™ in Eukaryotic Gene Expression, Vol.13, 2003, issue 1
Angus I. Lamond, Anthony K. L. Leung