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Critical Reviews™ in Eukaryotic Gene Expression
Импакт фактор: 2.156 5-летний Импакт фактор: 2.255 SJR: 0.649 SNIP: 0.599 CiteScore™: 3

ISSN Печать: 1045-4403
ISSN Онлайн: 2162-6502

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Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.v9.i3-4.70
pages 221-230

Interplay between Chromatin Modifying and Remodeling Complexes in Transcriptional Regulation

Rimma Belotserkovskaya
Molecular Genetics Program, The Wistar Institute, Philadelphia, PA 19104
Shelley L. Berger
Molecular Genetics Program, The Wistar Institute, Philadelphia, PA 19104

Краткое описание

The question of a possible functional relationship between different chromatin-altering enzymatic activities is of great interest. Several remarkable parallels have been revealed regarding the action of the remodeling complex SWI/SNF and the histone acetylation complex SAGA during transcriptional activation in S. cerevisiae. Many promoters, but not all, that require one complex require the other as well. Mutations that disrupt both complexes cause much more severe phenotypes than single mutations. Both types of complexes are recruited to specific promoters by interaction with DNA-bound acidic activators, resulting in targeted acetylation and transcriptional activation. Taken together the data argue for independent mechanisms, but similar recruitment and functional interplay between these two types of chromatin-altering activities.

Ключевые слова: SWI/SNF, SAGA, chromatin remodeling, histone modification.

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