Доступ предоставлен для: Guest
Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции
Critical Reviews™ in Eukaryotic Gene Expression
Импакт фактор: 1.841 5-летний Импакт фактор: 1.927 SJR: 0.649 SNIP: 0.516 CiteScore™: 1.96

ISSN Печать: 1045-4403
ISSN Онлайн: 2162-6502

Том 29, 2019 Том 28, 2018 Том 27, 2017 Том 26, 2016 Том 25, 2015 Том 24, 2014 Том 23, 2013 Том 22, 2012 Том 21, 2011 Том 20, 2010 Том 19, 2009 Том 18, 2008 Том 17, 2007 Том 16, 2006 Том 15, 2005 Том 14, 2004 Том 13, 2003 Том 12, 2002 Том 11, 2001 Том 10, 2000 Том 9, 1999 Том 8, 1998 Том 7, 1997 Том 6, 1996 Том 5, 1995 Том 4, 1994

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukaryotGeneExpr.2014012215
pages 357-378

Current Major Advances in the Regulation of Milk Protein Gene Expression

Xi Qian
Laboratory of Lactation and Metabolic Physiology, Department of Animal Science, University of Vermont, Burlington, VT
Feng-Qi Zhao
Laboratory of Lactation and Metabolic Physiology, Department of Animal Science, University of Vermont, Burlington, VT

Краткое описание

During lactation, functionally differentiated mammary epithelial cells convert circulating nutrients into various milk components, providing all essential nutrients for the growth and development of mammal neonates. One of the major milk components is milk protein, which includes the casein and whey proteins. Regulation of milk protein gene expression is dependent on hormonal and developmental cues that modulate the activity of specific transcription factors and change the chromatin structure in mammary epithelial cells. Understanding the underlying mechanisms involved in mammary-specific milk protein gene regulation will help improve the yield, quality, and efficiency of milk production and identify important signaling factors and pathways involved in mammary development, differentiation, lactation, and disease. In this review we first review advances in the understanding of the regulatory mechanisms of milk protein genes by hormones, growth factors, and the extracellular matrix, with a focus on transcriptional regulation. We then discuss the relationship between chromatin structure and milk protein gene expression from an epigenetic perspective. Finally, we summarize recent achievements using the mammary gland as a bioreactor for producing pharmaceutical proteins for human use.

Articles with similar content:

MicroRNA and Senescence: The Senectome, Integration and Distributed Control
Critical Reviews™ in Oncogenesis, Vol.18, 2013, issue 4
Alan E. Bilsland, John Revie, W. Nicol Keith
Transcription Regulator Yin-Yang 1: From Silence to Cancer
Critical Reviews™ in Oncogenesis, Vol.16, 2011, issue 3-4
Weidong Zhu, Hermes Garban, Samuel Y. Olson
Coactivation and Corepression in Transcriptional Regulation by Steroid/Nuclear Hormone Receptors
Critical Reviews™ in Eukaryotic Gene Expression, Vol.8, 1998, issue 2
J. Don Chen, Hui Li
Targeting the Regulatory Machinery of BIM for Cancer Therapy
Critical Reviews™ in Eukaryotic Gene Expression, Vol.22, 2012, issue 2
Steven Grant, Hisashi Harada
Architectural Genetic and Epigenetic Control of Regulatory Networks: Compartmentalizing Machinery for Transcription and chromatin remodeling in nuclear Microenvironments
Critical Reviews™ in Eukaryotic Gene Expression, Vol.20, 2010, issue 2
Sayyed Kaleem Zaidi, Janet L. Stein, Jane B. Lian, Martin Montecino, Jeffrey A. Nickerson, Andre J. van Wijnen, Gary S. Stein, Anthony N. Imbalzano