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ISSN Печать: 1045-4403
ISSN Онлайн: 2162-6502
Indexed in
Ductal Carcinoma In Situ: A Brief Review of Treatment Variation and Impacts on Patients and Society
Краткое описание
Nearly 20% of all breast cancer cases are ductal carcinoma in situ (DCIS), with over 60,000 cases diagnosed each year. Many of these cases would never cause clinical symptoms or threaten the life of the woman; however, it is currently impossible to distinguish which lesions will progress to invasive disease from those that will not. DCIS is generally associated with an excellent prognosis regardless of the treatment pathway, but there is variation in treatment aggressiveness that seems to exceed the medical uncertainty associated with DCIS management. Therefore, it would seem that a significant proportion of women with DCIS receive more extensive treatment than is needed. This overtreatment of DCIS is a growing concern among the breast cancer community and has implications for both the patient (via adverse treatment-related effects, as well as out-of-pocket costs) and society (via economic costs and the public health and environmental harm resulting from health care delivery). This article discusses DCIS treatment pathways and their implications for patients and society and calls for further research to examine the factors that are leading to such wide variation in treatment decisions.
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Margolis Ryan, Wessner Corinne, Stanczak Maria, Liu Ji-Bin, Li Jingzhi, Nam Kibo, Forsberg Flemming, Eisenbrey John R., Monitoring Progression of Ductal Carcinoma In Situ Using Photoacoustics and Contrast-Enhanced Ultrasound, Translational Oncology, 12, 7, 2019. Crossref
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Chien Ju-Chun, Liu Wen-Shan, Huang Wei-Tzu, Shih Liang-Chung, Liu Wen-Chung, Chen Yu-Chia, Chou Kang-Ju, Shiue Yow-Ling, Lin Pei-Chin, Local treatment options for young women with ductal carcinoma in situ: A systematic review and meta-analysis comparing breast conserving surgery with or without adjuvant radiotherapy, and mastectomy, The Breast, 63, 2022. Crossref