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Critical Reviews™ in Eukaryotic Gene Expression
Импакт фактор: 2.156 5-летний Импакт фактор: 2.255 SJR: 0.649 SNIP: 0.599 CiteScore™: 3

ISSN Печать: 1045-4403
ISSN Онлайн: 2162-6502

Выпуски:
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Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukaryotGeneExpr.2014007896
pages 39-53

MicroRNAs in Gastric Cancer Metastasis

Zhaoqi Shi
Department of General Surgery, 1st Affiliated Hospital of Xi'an Jiao Tong University, Xi'an, 710061, Shaan'xi Province, China
Qingxia Wei
Department of Development and Stem Cell Biology, The Hospital for Sick Children, University of Toronto, Toronto, M5G1X8, ON, Canada
Junjun She
Department of General Surgery, 1st Affiliated Hospital of Xi'an Jiao Tong University, Xi'an, 710061, Shaan'xi Province, China

Краткое описание

Gastric cancer (GC) is common worldwide and has a high rate of metastasis. The underlying molecular mechanism of metastasis are not entirely clear. MicroRNAs (miRNAs) are small, non-coding RNA molecules that regulate gene expression post-transcriptionally and are reported to be involved in multiple steps of tumor metastasis. Clarifying their roles in GC metastasis will improve understanding of this disease. Here, we review the involvement of miRNAs in multiple steps of GC metastasis, including epithelial−mesenchymal transitions, anoikis, angiogenesis, invasion, and migration. The clinical application of miRNAs as prognostic biomarkers in GC is also discussed.

Ключевые слова: microRNA, gastric cancer, metastasis

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