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Critical Reviews™ in Eukaryotic Gene Expression

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ISSN Печать: 1045-4403

ISSN Онлайн: 2162-6502

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.6 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.2 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00058 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.33 SJR: 0.345 SNIP: 0.46 CiteScore™:: 2.5 H-Index: 67

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Bioenergetics for Hepatocyte Polarization: Coordination of Multiple Cellular Organelles and the Master Regulator AMPK

Том 29, Выпуск 5, 2019, pp. 483-497
DOI: 10.1615/CritRevEukaryotGeneExpr.2019029911
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Краткое описание

Hepatocytes have well-defined polarized morphological structure. Establishment and maintenance of cellular polarity is crucial to the function and viability of hepatocytes. Many disorders, both genetic and acquired, and drugs can impair hepatocyte polarization resulting in liver dysfunction and injury. Hepatocyte polarization is an energy-dependent cellular process. Hence, cellular energy metabolism can significantly affect the polarized morphology and function of hepatocytes. Recent in vitro studies have demonstrated that multiple cellular organelles, including mitochondria, auto-phagosomes and lipid droplets, are involved in the utilization of energy for hepatocyte polarization; also, AMP-dependent kinase (AMPK), a key cellular energy sensor, regulates the function and activities of these cellular organelles and thus plays an important role in bioenergetics for hepatocyte polarization. This review provides the latest understanding on how mitochondria, autophagosomes, and lipid droplets coordinate energy production, and it addresses how AMPK activation regulates these key cellular organelles for energy production during hepatocyte polarization. Furthermore, the review suggests potential directions for future research.

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ЦИТИРОВАНО В
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