Доступ предоставлен для: Guest
Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции
Critical Reviews™ in Eukaryotic Gene Expression
Импакт фактор: 1.841 5-летний Импакт фактор: 1.927 SJR: 0.649 SNIP: 0.516 CiteScore™: 1.96

ISSN Печать: 1045-4403
ISSN Онлайн: 2162-6502

Выпуски:
Том 29, 2019 Том 28, 2018 Том 27, 2017 Том 26, 2016 Том 25, 2015 Том 24, 2014 Том 23, 2013 Том 22, 2012 Том 21, 2011 Том 20, 2010 Том 19, 2009 Том 18, 2008 Том 17, 2007 Том 16, 2006 Том 15, 2005 Том 14, 2004 Том 13, 2003 Том 12, 2002 Том 11, 2001 Том 10, 2000 Том 9, 1999 Том 8, 1998 Том 7, 1997 Том 6, 1996 Том 5, 1995 Том 4, 1994

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.v21.i2.50
pages 155-176

The Synthesis of C8-Aryl Purines, Nucleosides and Phosphoramidites

Nissa M. Thomsen
Basic Pharmaceutical Sciences, School of Pharmacy, West Virginia University, P.O. Box 9530, Morgantown, WV 26505
Vorasit Vongsutilers
Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, 10330, Thailand
Peter Gannett
West Virginia University

Краткое описание

C8-Aryl purines, their nucleosides, and phosphoramidites has been synthetic targets for more than 60 years. Interest in these compounds stems from their utility as fluorescent markers, they have therapeutic uses, are biomarkers, biomolecular probes, supramolecular building blocks, and for conformational studies. Until recently, the selective arylation of the C8-position of purines has been a challenging task. Several approaches have been explored including building them up from a pyrimidine or selective C8-modification of an unsubstituted purine. Neither of these approaches has proven to have broad scope. The discovery that C8-aryl purine nucleosides can be made via the Suzuki cross-coupling reaction has allowed a diverse array of analogues to be prepared and, in turn, the corresponding phosphoramidites. The latter is particularly significant as C8-aryl purine adducts are a major mutation observed from aromatic carcinogens and ready access to C8-aryl phosporamidites will facilitate the synthesis and study of C8-aryl purine biomarkers and modified oligonucleotides.


Articles with similar content:

Mucosal Drug Delivery: Membranes, Methodologies, and Applications
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.21, 2004, issue 3
Bozena Michniak, Yifan Song, Rashmi Thakur, Victor M. Meidan, Yiping Wang
Chemical, Pharmacological, and Biological Characterization of the Culinary-Medicinal Honey Mushroom, Armillaria mellea (Vahl) P. Kumm. (Agaricomycetideae): A Review
International Journal of Medicinal Mushrooms, Vol.13, 2011, issue 2
Katarzyna Sulkowska-Ziaja, Halina Ekiert, Malgorzata Wolkowska, Bozena Muszynska
Applications of Microdialysis Methodology in Nonhuman Primates: Practice and Rationale
Critical Reviews™ in Neurobiology, Vol.14, 2000, issue 2
Charles W. Bradberry
EVALUATION OF GIM AS A GREENER INSENSITIVE MELT-CAST EXPLOSIVE
International Journal of Energetic Materials and Chemical Propulsion, Vol.11, 2012, issue 1
Patrick Brousseau, Fanny Monteil-Rivera, Sylvie Rocheleau, Geoffrey I. Sunahara, Zorana Radovic-Hrapovic, Sebastien Cote, Pascal Beland, Jalal Hawari, Andre Marois, Sylvie Brochu, Serge Trudel, Richard Martel, Guy Ampleman, Sonia Thiboutot
Solid Self-Nanoemulsifying Delivery Systems as a Platform Technology for Formulation of Poorly Soluble Drugs
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.25, 2008, issue 1
Farhan Jalees Ahmad, Gulam Mustafa, Tripta Bansal, Sushama Talegaonkar, Zeenat I. Khan, Roop K. Khar