Доступ предоставлен для: Guest
Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции
Critical Reviews™ in Eukaryotic Gene Expression
Импакт фактор: 1.841 5-летний Импакт фактор: 1.927 SJR: 0.627 SNIP: 0.516 CiteScore™: 1.96

ISSN Печать: 1045-4403
ISSN Онлайн: 2162-6502

Выпуски:
Том 29, 2019 Том 28, 2018 Том 27, 2017 Том 26, 2016 Том 25, 2015 Том 24, 2014 Том 23, 2013 Том 22, 2012 Том 21, 2011 Том 20, 2010 Том 19, 2009 Том 18, 2008 Том 17, 2007 Том 16, 2006 Том 15, 2005 Том 14, 2004 Том 13, 2003 Том 12, 2002 Том 11, 2001 Том 10, 2000 Том 9, 1999 Том 8, 1998 Том 7, 1997 Том 6, 1996 Том 5, 1995 Том 4, 1994

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.v21.i2.40
pages 143-153

Molecular Parameters of Head and Neck Cancer Metastasis

Sanjay L. Bhave
Department of Otolaryngology-Head and Neck Surgery, The Ohio State University Medical Center; Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, The Ohio State University Comprehensive Cancer Center, Columbus OH 43210
Theodoras N. Teknos
Department of Otolaryngology-Head and Neck Surgery, The Ohio State University Medical Center; Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210
Quintin Pan
The Ohio State University Medical Center

Краткое описание

Metastasis remains a major cause of mortality in patients with head and neck squamous cell carcinoma (HNSCC). HNSCC patients with metastatic disease have extremely poor prognoses, with an average survival rate of less than a year. Metastasis is an intricate sequential process that requires a discrete population of tumor cells to possess the capacity to intravasate from the primary tumor into systemic circulation, survive in circulation, extravasate at a distant site, and proliferate in a foreign, hostile environment. Literature has accumulated to provide mechanistic insight into several signal transduction pathways, receptor tyro-sine kinases (RTKs), signal transducer and activator of transcription 3 (Stat3), Rho GTPases, protein kinase Cε (PKCsε), and nuclear factor-κB (NF-κB), that are involved in mediating a metastatic tumor cell phenotype in HN-SCC. Herein we highlight accrued information regarding the key molecular parameters of HNSCC metastasis.

Ключевые слова: HNSCC, squamous cell carcinoma, migration, invasion

Articles with similar content:

Viral Infection and Cancer: The NF-κB/Snail/RKIP Loop Regulates Target Cell Sensitivity to Apoptosis by Cytotoxic Lymphocytes
Critical Reviews™ in Immunology, Vol.30, 2010, issue 1
Stavroula Baritaki, Benjamin Bonavida
Regulatory Mechanisms Operative in Osteoclasts
Critical Reviews™ in Eukaryotic Gene Expression, Vol.14, 2004, issue 4
Sakamuri V. Reddy
Signaling Networks that Control the Lineage Commitment and Differentiation of Bone Cells
Critical Reviews™ in Eukaryotic Gene Expression, Vol.19, 2009, issue 1
Shuying Yang, Wei Chen, Carrie S. Soltanoff, Yi-Ping Li
NPR-A: A Therapeutic Target in Inflammation and Cancer
Critical Reviews™ in Eukaryotic Gene Expression, Vol.25, 2015, issue 1
Jia Zhang, Junhai Li, Yan Yan, Jiansheng Wang, Ya Yang, Jingkun Qu, Min Li
Aberrant Receptor Signaling and Trafficking as Mechanisms in Oncogenesis
Critical Reviews™ in Oncogenesis, Vol.13, 2007, issue 1
Tor Erik Rusten, Kaisa Haglund, Harald Stenmark