Доступ предоставлен для: Guest
Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции
Critical Reviews™ in Eukaryotic Gene Expression
Импакт фактор: 1.841 5-летний Импакт фактор: 1.927 SJR: 0.627 SNIP: 0.516 CiteScore™: 1.96

ISSN Печать: 1045-4403
ISSN Онлайн: 2162-6502

Том 29, 2019 Том 28, 2018 Том 27, 2017 Том 26, 2016 Том 25, 2015 Том 24, 2014 Том 23, 2013 Том 22, 2012 Том 21, 2011 Том 20, 2010 Том 19, 2009 Том 18, 2008 Том 17, 2007 Том 16, 2006 Том 15, 2005 Том 14, 2004 Том 13, 2003 Том 12, 2002 Том 11, 2001 Том 10, 2000 Том 9, 1999 Том 8, 1998 Том 7, 1997 Том 6, 1996 Том 5, 1995 Том 4, 1994

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.v21.i2.70
pages 187-206

Understanding the Skeletal Pathology of Type 1 and 2 Diabetes Mellitus

Laura McCabe
Michigan State University
Jing Zhang
Michigan State University, Department of Physiology
Sandi Raehtz
Michigan State University, Department of Physiology

Краткое описание

Diabetes affects over 25 million people and is characterized by hyperglycemia resulting from a lack of insulin or reduced insulin sensitivity. A serious complication of diabetes is the increase in fracture risk observed in both type 1 and type 2 diabetic patients. This review focuses on some of the cellular and mechanistic causes of diabetes-induced fracture risk. Type 1 and type 2 diabetes most likely have unique and overlapping mechanisms of bone loss. While type 1 diabetes is associated with reduced bone mineral density, this is not usually seen in type 2 diabetes. Hyperglycemia, present in both type 1 and 2 diabetes, alters bone matrix proteins such as collagen I through nonenzymatic glycation, which can decrease bone toughness and increase fracture risk even in the absence of bone loss. Diabetes is also associated with increased inflammation and altered adipokine and calcitrophic hormone levels, which further contribute to bone pathophysiology. As medical advances significantly lengthen patient lifespan, exposure to diabetic conditions increases and correspondingly so do disease complications. Further research to identify molecular pathways in diabetes-associated bone pathology will provide the basis for therapeutic targets/directions to increase treatment options and improve patient health and well-being.

Articles with similar content:

Nursing Home Fractures: A Challenge and a Solution
Journal of Environmental Pathology, Toxicology and Oncology, Vol.29, 2010, issue 1
Jill J. Dahlstrom, William B. Long III, Shelley S. Mason, Richard Edlich, Erin M. Swainston, K. Dean Gubler
Rehabilitation Approaches to the Prevention of Osteoporosis and Osteoporotic Fractures
Critical Reviews™ in Physical and Rehabilitation Medicine, Vol.19, 2007, issue 1
Patricia A. Downey, Susan B. Perry
State of the Evidence Regarding the Effect of Water Exercises on Bone Outcomes in Postmenopausal Women with Osteoporotic Vertebral Fractures
Critical Reviews™ in Physical and Rehabilitation Medicine, Vol.23, 2011, issue 1-4
Norma J MacIntyre, A.M. Bonnyman
Mechanisms Behind the Anti-inflammatory Actions of Insulin
Critical Reviews™ in Immunology, Vol.31, 2011, issue 4
Morley D. Hollenberg, Eric Hyun, Rithwik Ramachandran, Nathalie Vergnolle
Exercise Programs Designed and Dosed to Improve Bone Mineral Density in Children with Cerebral Palsy
Critical Reviews™ in Physical and Rehabilitation Medicine, Vol.28, 2016, issue 4
Mary E. Gannotti, Erica L. Breive, Kristen Miller, Rebecca A. Cameron, Robert Mobyed