Доступ предоставлен для: Guest
Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции
Critical Reviews™ in Eukaryotic Gene Expression
Импакт фактор: 1.841 5-летний Импакт фактор: 1.927 SJR: 0.627 SNIP: 0.516 CiteScore™: 1.96

ISSN Печать: 1045-4403
ISSN Онлайн: 2162-6502

Выпуски:
Том 29, 2019 Том 28, 2018 Том 27, 2017 Том 26, 2016 Том 25, 2015 Том 24, 2014 Том 23, 2013 Том 22, 2012 Том 21, 2011 Том 20, 2010 Том 19, 2009 Том 18, 2008 Том 17, 2007 Том 16, 2006 Том 15, 2005 Том 14, 2004 Том 13, 2003 Том 12, 2002 Том 11, 2001 Том 10, 2000 Том 9, 1999 Том 8, 1998 Том 7, 1997 Том 6, 1996 Том 5, 1995 Том 4, 1994

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukaryotGeneExpr.2015013770
pages 191-197

Long Non-Coding RNA Urothelial Carcinoma Associated 1 (UCA1): Insight into Its Role in Human Diseases

Feng Li
Department of Pharmacology, School of Pharmaceutical Sciences, Central South University, Changsha, Hunan, China
Chang-Ping Hu
Department of Pharmacology, School of Pharmaceutical Sciences, Central South University, Changsha, Hunan, China

Краткое описание

Long non-coding RNA (lncRNA) is a type of DNA transcript that is longer than 200 nucleotides (nt). They do not encode proteins, but they control gene expression on various levels. Long non-coding RNA metastasis-associated urothelial carcinoma associated 1 (UCA1) was confirmed to play an important role in the occurrence and development of many tumor and non-tumor diseases. UCA1 mainly interacts with proteins in the nucleus, regulating gene expression in transcription and post-transcription. UCA1 is highly expressed in tumor tissue, and therefore can be related to clinical parameters. It may regulate tumor cell proliferation, invasion, apoptosis, and migration, so UCA1 can be applied in clinical prognosis and targeted therapy. This review mainly elaborates the roles of UCA1 in tumor diseases of the respiratory, digestive, reproductive, and urinary systems; and in non-tumor diseases.

Ключевые слова: lncRNA, biomarker, tumor, clinical prognosis, targeted therapy

Articles with similar content:

miRNA: A Diagnostic and Therapeutic Tool for Pancreatic Cancer
Critical Reviews™ in Eukaryotic Gene Expression, Vol.27, 2017, issue 3
Muhammad Imran Qadir, Arooj Faheem
Altered Expression of Histone Deacetylases in Cancer
Critical Reviews™ in Oncogenesis, Vol.20, 2015, issue 1-2
Carmen Jeronimo, Rui Manuel Ferreira Henrique, Diana Montezuma
Deacetylation of Chromatin and Gene Expression Regulation: A New Target for Epigenetic Therapy
Critical Reviews™ in Oncogenesis, Vol.20, 2015, issue 1-2
Heidi Olzscha, Nicholas B. La Thangue, Semira Sheikh
Histone Deacetylases and Mechanisms of Regulation of Gene Expression
Critical Reviews™ in Oncogenesis, Vol.20, 2015, issue 1-2
Hong Ping Chen, Ting C. Zhao, Yu Tina Zhao
MicroRNAs in Bladder Cancer: Expression Profiles, Biological Functions, Regulation, and Clinical Implications
Critical Reviews™ in Eukaryotic Gene Expression, Vol.24, 2014, issue 1
Zhaoqi Shi, Mingxin Zhang, Junjun She, Qingxia Wei