Доступ предоставлен для: Guest
Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции
Critical Reviews™ in Eukaryotic Gene Expression
Импакт фактор: 1.841 5-летний Импакт фактор: 1.927 SJR: 0.649 SNIP: 0.516 CiteScore™: 1.96

ISSN Печать: 1045-4403
ISSN Онлайн: 2162-6502

Выпуски:
Том 29, 2019 Том 28, 2018 Том 27, 2017 Том 26, 2016 Том 25, 2015 Том 24, 2014 Том 23, 2013 Том 22, 2012 Том 21, 2011 Том 20, 2010 Том 19, 2009 Том 18, 2008 Том 17, 2007 Том 16, 2006 Том 15, 2005 Том 14, 2004 Том 13, 2003 Том 12, 2002 Том 11, 2001 Том 10, 2000 Том 9, 1999 Том 8, 1998 Том 7, 1997 Том 6, 1996 Том 5, 1995 Том 4, 1994

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukaryotGeneExpr.2015013838
pages 199-202

AKT as Locus of Cancer Positive Loops Conversion and Chemotherapy

Ziv Radisavljevic
Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, Massachusetts 02115

Краткое описание

A cancer positive-feedback loops conversion is the phenomenon and principal mechanism for AKT locus chemotherapy. Such chemotherapy is the approach to target cancer robustness and complexity through the AKT signaling locus. The hypoxic cancer microenvironment generates a powerful signaling interactome with positive-feedback loops that generates cancer robustness through the AKT locus. This complexity and robustness can be successfully halted in leukemia, lymphoma, myeloma, plasmocytoma, sarcoma, and carcinoma by converting cancer positive-feedback loops into negative-feedback loops, achieved through the AKT dephosphorylation by redox balancing change. The hyperphosphorylated AKT locus is down-regulated completely to AKT dephosphorylation by redox balancing change, causing conversion of positive-feedback loops and the disappearance of malignant robustness as a direct effect of AKT locus chemotherapy.


Articles with similar content:

Antitumor Initiating Potential of Rosmarinic Acid in 7,12-Dimethylbenz(a)anthracene-Induced Hamster Buccal Pouch Carcinogenesis
Journal of Environmental Pathology, Toxicology and Oncology, Vol.30, 2011, issue 3
Shanmugam Manoharan, Chezhiyan Anusuya
Chemoprevention of Colon Cancer by iNOS-Selective Inhibitors
Forum on Immunopathological Diseases and Therapeutics, Vol.3, 2012, issue 2
Chinthalapally V. Rao, Naveena B. Janakiram
Yin Yang 1 in Human Cancer
Critical Reviews™ in Oncogenesis, Vol.16, 2011, issue 3-4
Richard Byers, Khimara Naidoo, Sarah Nicholson, Helen Whitehouse
Precision in Diagnostic Molecular Pathology based on Immunohistochemistry
Critical Reviews™ in Oncogenesis, Vol.22, 2017, issue 5-6
Qiu-Yuan Xia, Ru Fang, Xiao-Tong Wang, Xiao-Jun Zhou, Qiu Rao
A Review of Molecular Events of Cadmium-Induced Carcinogenesis
Journal of Environmental Pathology, Toxicology and Oncology, Vol.33, 2014, issue 3
Chendil Damodaran, Joe Luevano