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Critical Reviews™ in Eukaryotic Gene Expression

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ISSN Печать: 1045-4403

ISSN Онлайн: 2162-6502

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.6 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.2 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00058 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.33 SJR: 0.345 SNIP: 0.46 CiteScore™:: 2.5 H-Index: 67

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Protein Tyrosine Phosphatases in Osteoclasts

Том 17, Выпуск 1, 2007, pp. 49-72
DOI: 10.1615/CritRevEukarGeneExpr.v17.i1.40
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Краткое описание

Osteoclasts are large cells derived from the monocyte-macrophage hematopoietic cell lineage, whose primary function is to degrade bone in various physiological contexts. Reversible phosphorylation of tyrosine residues in proteins is known to play significant roles in regulating the function of osteoclasts, much as it does in other cell types. Protein tyrosine phosphatases (PTPs) are among the major regulators of this process, but significant gaps exist in our knowledge of which phosphatases function in osteoclasts and the nature of their precise cellular and molecular roles. We review here the roles of the four tyrosine phosphatases that are known currently to be expressed in osteoclasts—PTPRO, PTP epsilon (PTPε), SHP-1, and PTP-PEST. Of these, PTPRO and PTPε support osteoclast activity, whereas SHP-1 inhibits it. Much future research is required to uncover additional PTPs that function in osteoclasts and provide full molecular-level accounting of their respective roles in osteoclasts.

ЦИТИРОВАНО В
  1. Chellaiah Meenakshi A., Schaller Michael D., Activation of Src kinase by protein-tyrosine phosphatase-PEST in osteoclasts: Comparative analysis of the effects of bisphosphonate and protein-tyrosine phosphatase inhibitor on Src activation in vitro, Journal of Cellular Physiology, 220, 2, 2009. Crossref

  2. Tang Xiao-Lu, Wang Chang-Nan, Zhu Xiao-Yan, Ni Xin, Protein tyrosine phosphatase SHP-1 modulates osteoblast differentiation through direct association with and dephosphorylation of GSK3β, Molecular and Cellular Endocrinology, 439, 2017. Crossref

  3. Lau Kin-Hing William, Sheng Matilda H.-C., A novel miR17 /protein tyrosine phosphatase-oc/EphA4 regulatory axis of osteoclast activity, Archives of Biochemistry and Biophysics, 650, 2018. Crossref

  4. Lountos George T., Raran-Kurussi Sreejith, Zhao Bryan M., Dyas Beverly K., Burke Terrence R., Ulrich Robert G., Waugh David S., High-resolution crystal structures of the D1 and D2 domains of protein tyrosine phosphatase epsilon for structure-based drug design, Acta Crystallographica Section D Structural Biology, 74, 10, 2018. Crossref

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