Выходит 6 номеров в год
ISSN Печать: 1045-4403
ISSN Онлайн: 2162-6502
Indexed in
NPR-A: A Therapeutic Target in Inflammation and Cancer
Краткое описание
Natriuretic peptide receptor A (NPR-A) is the receptor for atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP). NPR-A plays critical physiological and pathophysiological roles in several target cell and tissue system processes, such as cell growth, apoptosis, proliferation, and inflammation. Accumulating data demonstrate that NPR-A is involved in immune and inflammatory reactions and is a potential target in inflammation treatment. It is expressed in various cancer cells and is important for tumor growth. A recent study indicated that NPR-A signaling can regulate stem cell recruitment and angiogenesis. This signaling can serve as a model for studying the linkage between inflammation and tumorigenesis. In this review we highlight the mechanisms by which NPR-A affects signaling pathways involved in inflammation and cancer, and we discuss its potential as a novel target in inflammation, cancer, and cancer-related inflammation.
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Kalaiarasu Lakshmi Priya, Subramanian Vimala, Sowndharrajan Boopathi, Vellaichamy Elangovan, Insight into the Anti-Inflammatory Mechanism of Action of Atrial Natriuretic Peptide, a Heart Derived Peptide Hormone: Involvement of COX-2, MMPs, and NF-kB Pathways, International Journal of Peptide Research and Therapeutics, 22, 4, 2016. Crossref
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Mezzasoma Letizia, Peirce Matthew, Minelli Alba, Bellezza Ilaria, Natriuretic Peptides: The Case of Prostate Cancer, Molecules, 22, 10, 2017. Crossref
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Kawagoe Chihiro, Sato Yuji, Toida Tatsunori, Nakagawa Hideto, Yamashita Yasuhiro, Fukuda Akihiro, Iwatsubo Shuji, Fujimoto Shouichi, N-terminal-pro-B-type-natriuretic peptide associated with 2-year mortality from both cardiovascular and non-cardiovascular origins in prevalent chronic hemodialysis patients, Renal Failure, 40, 1, 2018. Crossref
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Polina Iuliia, Domondon Mark, Fox Rebecca, Sudarikova Anastasia V., Troncoso Miguel, Vasileva Valeriia Y., Kashyrina Yuliia, Gooz Monika Beck, Schibalski Ryan S., DeLeon-Pennell Kristine Y., Fitzgibbon Wayne R., Ilatovskaya Daria V., Differential effects of low-dose sacubitril and/or valsartan on renal disease in salt-sensitive hypertension, American Journal of Physiology-Renal Physiology, 319, 1, 2020. Crossref
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Mezzasoma Letizia, Talesa Vincenzo Nicola, Romani Rita, Bellezza Ilaria, ANP and BNP Exert Anti-Inflammatory Action via NPR-1/cGMP Axis by Interfering with Canonical, Non-Canonical, and Alternative Routes of Inflammasome Activation in Human THP1 Cells, International Journal of Molecular Sciences, 22, 1, 2020. Crossref
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Mezzasoma Letizia, Talesa Vincenzo Nicola, Costanzi Egidia, Bellezza Ilaria, Natriuretic Peptides Regulate Prostate Cells Inflammatory Behavior: Potential Novel Anticancer Agents for Prostate Cancer, Biomolecules, 11, 6, 2021. Crossref
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Ilatovskaya Daria V., Levchenko Vladislav, Winsor Kristen, Blass Gregory R., Spires Denisha R., Sarsenova Elizaveta, Polina Iuliia, Zietara Adrian, Paterson Mark, Kriegel Alison J., Staruschenko Alexander, Effects of elevation of ANP and its deficiency on cardiorenal function, JCI Insight, 7, 9, 2022. Crossref
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Santhekadur Prasanna K., Kumar Divya P., Seneshaw Mulugeta, Mirshahi Faridoddin, Sanyal Arun J., The multifaceted role of natriuretic peptides in metabolic syndrome, Biomedicine & Pharmacotherapy, 92, 2017. Crossref
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Xu Mengjiao, Liu Xingzhu, Li Ping, Yang Yadong, Zhang Wenyuan, Zhao Siyu, Zeng Ying, Zhou Xile, Zeng Ling-hui, Yang Geng, Modified natriuretic peptides and their potential roles in cancer treatment, Biomedical Journal, 45, 1, 2022. Crossref
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Kanoh Hirotaka, Iwashita Shinzo, Kuraishi Takayuki, Goto Akira, Fuse Naoyuki, Ueno Haruna, Nimura Mariko, Oyama Tomohito, Tang Chang, Watanabe Ryo, Hori Aki, Momiuchi Yoshiki, Ishikawa Hiroki, Suzuki Hiroaki, Nabe Kumiko, Takagaki Takeshi, Fukuzaki Masataka, Tong Li-Li, Yamada Sinya, Oshima Yoshiteru, Aigaki Toshiro, Dow Julian A.T., Davies Shireen-Anne, Kurata Shoichiro, cGMP signaling pathway that modulates NF-κB activation in innate immune responses, iScience, 24, 12, 2021. Crossref