Доступ предоставлен для: Guest
Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции
Critical Reviews™ in Eukaryotic Gene Expression
Импакт фактор: 2.156 5-летний Импакт фактор: 2.255 SJR: 0.649 SNIP: 0.599 CiteScore™: 3

ISSN Печать: 1045-4403
ISSN Онлайн: 2162-6502

Выпуски:
Том 30, 2020 Том 29, 2019 Том 28, 2018 Том 27, 2017 Том 26, 2016 Том 25, 2015 Том 24, 2014 Том 23, 2013 Том 22, 2012 Том 21, 2011 Том 20, 2010 Том 19, 2009 Том 18, 2008 Том 17, 2007 Том 16, 2006 Том 15, 2005 Том 14, 2004 Том 13, 2003 Том 12, 2002 Том 11, 2001 Том 10, 2000 Том 9, 1999 Том 8, 1998 Том 7, 1997 Том 6, 1996 Том 5, 1995 Том 4, 1994

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukaryotGeneExpr.v12.i2.20
18 pages

Complex Smad-Dependent Transcriptional Responses in Vertebrate Development and Human Disease

Leo A. van Grunsven
Laboratory of Molecular Biology (Celgen), University of Leuven; and Department of Developmental Biology (VIB7), Flanders Intel-university Institute for Biotechnology (VIB), Campus Gasthuisberg, BIdg. O&N, Herestraat 49, B-3000 Leuven, Belgium
Danny Huylebroeck
Laboratory of Molecular Biology (Celgen), University of Leuven; and Department of Developmental Biology (VIB7), Flanders Intel-university Institute for Biotechnology (VIB), Campus Gasthuisberg, BIdg. O&N, Herestraat 49, B-3000 Leuven, Belgium
Kristin Verschueren
Laboratory of Molecular Biology (Celgen), University of Leuven; and Department of Developmental Biology (VIB7), Flanders Intel-university Institute for Biotechnology (VIB), Campus Gasthuisberg, BIdg. O&N, Herestraat 49, B-3000 Leuven, Belgium

Краткое описание

Smad proteins mediate genomic responses to polypeptides of the transforming growth factor type b (TGF-b) family, affecting cellular proliferation and differentiation, adhesion, and death. Members of one class of these Smad proteins, the receptor-regulated Smads or R-Smads, accumulate in the nucleus on their activation byligand-bound complexes of serine-threonine kinase receptors at the cell surface. These effector proteins then participate directly in the regulation of gene expression by binding to DNA, interacting with transcription factors, and recruiting corepressors or coactivators to specific promoters. Although many nuclear Smad-interacting factors were isolated during the last 3 years, the field has recently taken a step beyond the characterization of the activity of these Smad-containing complexes on gene expression in vitro, as it addresses now their contribution to many processes in vivo. We have selected examples of such recent progress to illustrate the remarkable variation in the molecular mechanisms underlying Smad-dependent signaling depending on the non-Smad partner in the nucleus and their relevance to normal embryogenesis and consequences of their deregulation in human disorders and pathology.


Articles with similar content:

YY1 in Cell Differentiation and Tissue Development
Critical Reviews™ in Oncogenesis, Vol.22, 2017, issue 1-2
Huating Wang, Fengyuan Chen, Yu Zhao, Hao Sun
Structure and Function of Histone Methyltransferases
Critical Reviews™ in Eukaryotic Gene Expression, Vol.14, 2004, issue 3
Raymond C. Trievel
The Family of Retinoblastoma Proteins
Critical Reviews™ in Eukaryotic Gene Expression, Vol.11, 2001, issue 1-3
Antonio Giordano, Peter Stiegler
Cellular and Molecular Mechanisms Regulating Silica-Induced Adhesion Molecule Expression in Mice
Journal of Environmental Pathology, Toxicology and Oncology, Vol.20, 2001, issue Suppl.1
Charles Giardina, Andrea K. Hubbard, Michael Thibodeau
A Compilation and Classification of DNA Binding Sites for Protein Transcription Factors from Vertebrates
Critical Reviews™ in Eukaryotic Gene Expression, Vol.4, 1994, issue 2-3
Teni Boulikas