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Critical Reviews™ in Eukaryotic Gene Expression
Импакт фактор: 2.156 5-летний Импакт фактор: 2.255 SJR: 0.649 SNIP: 0.599 CiteScore™: 3

ISSN Печать: 1045-4403
ISSN Онлайн: 2162-6502

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Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukaryotGeneExpr.2020028598
pages 199-206

Paradoxical Role of Dengue Virus Envelope Protein Domain III Antibodies in Dengue Virus Infection

Sheeza Ali
Division of Molecular Virology and Infectious Diseases, Centre of Excellence in Molecular Biology (CEMB), University of the Punjab, Thokar Niaz Baig, Lahore, Pakistan
Samia Afzal
Division of Molecular Virology & Molecular Diagnostics, National Centre of Excellence in Molecular Biology (CEMB), University of the Punjab, Lahore, Pakistan
Muhammad Zubair Yousaf
Centres of Excellence in Science & Applied Technologies, Islamabad, Pakistan; Department of Biological Sciences, Forman Christian College (A Chartered University), Ferozpur Road, 54600, Lahore, Pakistan
Muhammad Shahid
Division of Molecular Virology and Infectious Diseases, Centre of Excellence in Molecular Biology (CEMB), University of the Punjab, Thokar Niaz Baig, Lahore, Pakistan
Iram Amin
Centre of Applied Molecular Biology (CAMB), University of the Punjab, Lahore-Pakistan; Division of Molecular Virology and Infectious Diseases, Centre of Excellence in Molecular Biology (CEMB), University of the Punjab, Lahore-Pakistan
Muhammad Idrees
Division of Molecular Virology and Infectious Diseases, Centre of Excellence in Molecular Biology (CEMB), University of the Punjab, Lahore-Pakistan; Hazara University, Khyber Pakhtunkhwa, Pakistan
Ayma Aftab
Division of Molecular Virology and Infectious Diseases, Centre of Excellence in Molecular Biology (CEMB), University of the Punjab, Thokar Niaz Baig, Lahore, Pakistan

Краткое описание

Every year, approximately 100 million individuals are infected with dengue viral infections. Severe dengue infection, characterized as dengue hemorrhagic fever, leads to loss of intravascular fluids and severe bleeding. During dengue virus (DENV) secondary infection, the body produces neutralizing antibodies that cause a strong immune response, resulting in severe hemolysis and plasma leakage. DENV infections in humans stimulate production of virus serotype-specific and cross-reactive antibodies. The envelope (E) protein of DENV contains potent antigenic sites, with one known as E protein domain III (EDIII). Studies of DENV EDIII in mouse models have shown that strongly neutralizing mouse monoclonal antibodies (mAbs) are DENV-serotype specific and bind to an epitope on EDIII that is unique to each serotype. Unlike DENV-serotype-specific mouse mAbs, cross-reactive mAbs that bind to EDIII have moderate-to-weak neutralizing activity. Studies with mouse mAbs resulted in identification and mapping of different epitopes on the lateral ridge of DENV EDIII.

ЛИТЕРАТУРА

  1. Pierson T, Diamond M. Vaccine evelopment as a means to control dengue virus pathogenesis: Do we know enough? Ann Rev Virol. 2014;1(1):375.

  2. Rodenhuis-Zybert IA, Wilschut J, Smit JM. Dengue virus life cycle: Viral and host factors modulating infectivity. Cell Mol Life Sci. 2010 Aug;67(16):2773-86. PubMed PMID: 20372965. Epub 2010/04/08. eng.

  3. Whitehead SS, Blaney JE, Durbin AP, Murphy BR. Prospects for a dengue virus vaccine. Nat Rev Microbiol. 2007 Jul;5(7):518-28. PubMed PMID: 17558424. Epub 2007/06/15.eng.

  4. Modis Y, Ogata S, Clements D, Harrison SC. A ligand-binding pocket in the dengue virus envelope glycoprotein. Proc Natl Acad Sci USA. 2003 Jun 10;100(12):6986-91. PubMed PMID: 12759475. PMCID: 165817. Epub 2003/05/22.eng.

  5. Kumar CS, Sharma S. Dengue virus infection. Natl Med J India. 2016 Dec 30;2016:29.

  6. Gregson A, Edelman R. Dengue virus infection. Pediat Infect Dis J. 2003;22(2):179-81.

  7. Halstead SB, editor. Tropical medicine science and practice. Dengue: Overview and history. Singapore: World Scientific Publishing Co.; 2008. pp. 1-28.

  8. Tuiskunen Back A, Lundkvist A. Dengue viruses-An overview. Infect Ecol Epidemiol. 2013;3(1):19839.

  9. Diamond MS, Pierson TC. Molecular insight into dengue virus pathogenesis and its implications for disease control. Cell. 2015;162(3):488-92.

  10. Simmons CP, Farrar JJ, van Vinh Chau N, Wills B. Dengue. New Engl J Med. 2012;366(15):1423-32.

  11. Hesse RR. Dengue virus evolution and virulence models. Clin Infect Dis. 2007;44(11):1462-6.

  12. Martina BE, Koraka P, Osterhaus AD. Dengue virus pathogenesis: An integrated view. Clin Microbiol Rev. 2009 Oct;22(4):564-81. PubMed PMID: 19822889. PM.

  13. Malavige GN, Fernando S, Fernando DJ, Seneviratne SL. Dengue viral infections. Postgrad Med J. 2004 Oct;80(948):588-601. PubMed PMID: 15466994. PM-CID: 1743110. Epub 2004/10/07.eng.

  14. Gurugama P, Garg P, Perera J, Wijewickrama A, Seneviratne SL. Dengue viral infections. Indian J Dermatol. 2010 Jan-Mar;55(1):68-78. PubMed PMID: PMC2856379.

  15. Guzman MG, Kouri G. Dengue: An update. Lancet Infect Dis. 2002 01/01;2(1):33-42.

  16. Simmons CP, Chau TNB, Thuy TT, Tuan NM, Hoang DM, Thien NT, Lien LB, Quy NT, Hieu NT, Hien TT, McElnea C, Young P, Whitehead S, Hung NT, Farrar J. Maternal antibody and viral factors in the pathogenesis of dengue virus in infants. J Infect Dis. 2007;196(3):416-24.

  17. Gibbons RV. Dengue conundrums. Int J Antimicrob Agents. 2010;36:S36-9.

  18. World Health Organization, UNICEF. Handbook for clinical management of dengue. Vol. viii. Geneva, Swit-zerland: WHO Institutional Repository for Information Sharing; 2012.

  19. World Health Organization. Comprehensive guideline for prevention and control of dengue and dengue haemorrhagic fever. Revised and expanded edition. New Delhi, India: WHO Regional Office for South-East Asia; 2011.

  20. Kalayanarooj S. Clinical manifestations and management of dengue/DHF/DSS. Trop Med Health. 2011;39(4 Suppl):S83-7.

  21. Mairuhu ATA, Wagenaar J, Brandjes DPM, van Gorp ECM. Dengue: An arthropod-borne disease of global importance. Eur J Clin Microbiol Infect Dis. 2004 Jun 01;23(6):425-33.

  22. Murphy BR, Whitehead SS. Immune response to dengue virus and prospects for a vaccine. Ann Rev Immunol. 2011;29:587-619.

  23. Perera R, Kuhn RJ. Structural proteomics of dengue virus. Curr Opin Microbiol. 2008;11(4):369-77.

  24. Soares RO, Caliri A. Stereochemical features of the envelope protein domain III of dengue virus reveals putative antigenic site in the five-fold symmetry axis. Biochim Biophys Acta. 2013 Jan;1834(1):221-30. PubMed PMID: 23009809. Epub 2012/09/27.eng.

  25. Green AM, Beatty PR, Hadjilaou A, Harris E. Innate immunity to dengue virus infection and subversion of antiviral responses. J Mol Biol. 2014 03/20;426(6):1148-60.

  26. Fahimi H, Sadeghizadeh M, Mohammadipour M. In silico analysis of an envelope domain III-based multivalent fusion protein as a potential dengue vaccine candidate. Clin Exp Vaccine Res. 2016 Jan;5(1):41-9. PubMed PMID: 26866023. PMCID: 4742598. Epub 2016/02/13.eng.

  27. Pierson TC, Fremont DH, Kuhn RJ, Diamond MS. Structural insights into the mechanisms of antibody-mediated neutralization of flavivirus infection: Implications for vaccine development. Cell Host Microbe. 2008;4(3):229-38.

  28. Pitcher TJ, Sarathy VV, Matsui K, Gromowski GD, Huang CY-H, Barrett AD. Functional analysis of dengue virus (DENV) type 2 envelope protein domain 3 type-specific and DENV complex-reactive critical epitope residues. J Gener Virol. 2015;96(2):288-93.

  29. Fibriansah G, Tan JL, Smith SA, de Alwis AR, Ng TS, Kostyuchenko VA, Ibarra KD, Wang J, Harris E, de Silva A. A potent antidengue human antibody preferentially recognizes the conformation of E protein monomers assembled on the virus surface. EMBO Mol Med. 2014 Mar;6(3):358-71.

  30. Lai C-Y, Tsai W-Y, Lin S-R, Kao C-L, Hu H-P, King C-C, Wu H-C, Chang G-J, Wang W-K. Antibodies to envelope glycoprotein of dengue virus during the natural course of infection are predominantly cross-reactive and recognize epitopes containing highly conserved residues at the fusion loop of domain II. J Virol. 2008;82(13): 6631-43.

  31. Valdes K, Alvarez M, Pupo M, Vazquez S, Rodriguez R, Guzman MG. Human dengue antibodies against structural and nonstructural proteins. Clin Diagnost Lab Immunol. 2000;7(5):856-7.

  32. Lin C-F, Wan S-W, Cheng H-J, Lei H-Y, Lin Y-S. Autoimmune pathogenesis in dengue virus infection. Viral Immunol. 2006;19(2):127-32.

  33. dos Santos FB, Miagostrovich MP, Nogueira RM, Schatzmayr HG, Riley LW, Harris E. Analysis of recombinant dengue virus polypeptides for dengue diagnosis and evaluation of the humoral immune response. Am J Trop Med Hyg. 2004 Aug;71(2):144-52.

  34. Lazaro-Olan L, Mellado-Sanchez G, Garcia-Cordero J, Escobar-Gutierrez A, Santos-Argumedo L, Gutierrez-Castaneda B, Cedillo-Barron L. Analysis of antibody response in human dengue patients from the Mexican coast using recombinant antigens. Vector Borne Zoonotic Dis. 2008;8(1):69-80.

  35. Flipse J, Smit JM. The complexity of a dengue vaccine: A review of the human antibody response. PLoS Negl Trop Dis. 2015 Jun 11;9(6):e0003749.

  36. Wahala W, Kraus AA, Haymore LB, Accavitti-Loper MA, de Silva AM. Dengue virus neutralization by human immune sera: Role of envelope protein domain III-reactive antibody. Virology. 2009;392(1):103-13.


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