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ISSN Печать: 1045-4403
ISSN Онлайн: 2162-6502
Indexed in
Androgen Action
Краткое описание
Androgens are C-19 steroids that provide major regulatory influences on male reproductive function. Testosterone, the principal androgenic steroid, is secreted by the Leydig cells of the testes. Both testosterone and its 5α reduced derivative 5α-dihydrotestosterone (DHT) are physiological ligands for the androgen receptor (AR). Ligand-activated AR acts as a nuclear transcription factor and mediates androgen action. AR, along with receptors for a number of C-21 steroids such as glucocorticoid, mineralocorticoid, and progesterone, share the same 15 base pair consensus element composed of 5’-GGA/TACAnnnTGTTCT-3’. Despite this cross-reactivity at the level of the DNA, physiologically, androgens regulate their target genes with a high degree of receptor specificity. Such a regulatory specificity appears to be due to multiphasic interactions involving enzymatic activation/inactivation of the steroid ligand, interaction with specific receptor-associated nuclear factors on or around the hormone response element, and differential regulation of the receptor gene expression. Conversion of testosterone to 5α-dihydrotestosterone in target cells is a widespread activation mechanism that amplifies the androgenic signal. Unlike the testosterone-AR complex, DHT-activated AR has a longer half-life, and thus prolongs androgen action. Oxido-reduction of androgens by 17β-hydroxysteroid dehydrogenase and sulfurylation by androgen sulfotransferase are two major pathways of androgen inactivation in target cells. Prenatal deprivation of androgen action, due to mutations in either the AR or the 5α-reductase gene, results in developmental abnormalities of male reproductive tissues and also cause partial or complete androgen-insensitivity syndromes. Elucidation of various molecular steps in androgen action is allowing development of improved therapeutic agents for the management of disorders of androgen action such as the prostatic hypertrophy and neoplasia.
-
Roy A.K., Lavrovsky Y., Song C.S., Chen S., Jung M.H., Velu N.K., Bi B.Y., Chatterjee B., , 55, 1998. Crossref
-
Choudhry Mashkoor A, Schwacha Martin G, Hubbard William J, Kerby Jeffrey D, Rue Loring W, Bland Kirby I, Chaudry Irshad H, GENDER DIFFERENCES IN ACUTE RESPONSE TO TRAUMA-HEMORRHAGE, Shock, 24, Supplement 1, 2005. Crossref
-
Prins Gail S., Jung Myeong H., Vellanoweth Robert L., Chatterjee Bandana, Roy Arun K., Age-dependent expression of the androgen receptor gene in the prostate and its implication in glandular differentiation and hyperplasia, Developmental Genetics, 18, 2, 1996. Crossref
-
Viger Robert S., Silversides David W., Tremblay Jacques J., , 70, 2005. Crossref
-
Finn Deborah A., Beadles-Bohling Amy S., Beckley Ethan H., Ford Matthew M., Gililland Katherine R., Gorin-Meyer Rebecca E., Wiren Kristine M., A New Look at the 5?-Reductase Inhibitor Finasteride, CNS Drug Reviews, 12, 1, 2006. Crossref
-
Lu Shifang, Simon Neal G., Wang Yu, Hu Shan, Neural androgen receptor regulation: Effects of androgen and antiandrogen, Journal of Neurobiology, 41, 4, 1999. Crossref
-
Raghavan Anilakumar Kandangath, Khanum Farhath, Singh Bawa Amarinder, Pharmacological and Therapeutic Properties of Propolis (Bee Glue), in Oxidative Stress in Vertebrates and Invertebrates, 2011. Crossref
-
Swerdloff Ronald S., Wang Christina, Dihydrotestosterone: A rationale for its use as a non-aromatizable androgen replacement therapeutic agent, Baillière's Clinical Endocrinology and Metabolism, 12, 3, 1998. Crossref
-
Watson Joanne M, Armitage Mary, Testosterone hormone replacement and its alternatives, Expert Opinion on Therapeutic Patents, 10, 6, 2000. Crossref
-
Gnanapragasam V.J., Robson C.N., Leung H.Y., Neal D.E., Androgen receptor signalling in the prostate, BJU International, 86, 9, 2001. Crossref
-
Kapp Robert W., Thomas John A., Toxicology of the Endocrine System, in General and Applied Toxicology, 2009. Crossref
-
Luo Haoshu, Liu Jiali, Kang Duo, Cui Sheng, Ontogeny of estrogen receptor alpha, estrogen receptor beta and androgen receptor, and their co-localization with Islet-1 in the dorsal root ganglia of sheep fetuses during gestation, Histochemistry and Cell Biology, 129, 4, 2008. Crossref
-
McIntyre Barry S., Barlow Norman J., Wallace Duncan G., Maness Susan C., Gaido Kevin W., Foster Paul M.D., Effects of in Utero Exposure to Linuron on Androgen-Dependent Reproductive Development in the Male Crl:CD(SD)BR Rat, Toxicology and Applied Pharmacology, 167, 2, 2000. Crossref
-
Kim Hyun-Jung, Park Young In, Dong Mi-Sook, Comparison of prostate cancer cell lines for androgen receptor-mediated reporter gene assays, Toxicology in Vitro, 20, 7, 2006. Crossref
-
Choudhry Mashkoor A., Schwacha Martin G., Matsutani Takeshi, Bland Kirby I., Chaudry Irshad H., Cellular, molecular and sexual dimorphic response to trauma-hemorrhage, International Congress Series, 1255, 2003. Crossref
-
Stoffel Erin C, Ulibarri Catherine M, Craft Rebecca M, Gonadal steroid hormone modulation of nociception, morphine antinociception and reproductive indices in male and female rats, Pain, 103, 3, 2003. Crossref
-
McIntyre Barry S, Vancutsem Paul M, Treinen Kimberley A, Morrissey Richard E, Effects of perinatal loratadine exposure on male rat reproductive organ development, Reproductive Toxicology, 17, 6, 2003. Crossref
-
Beyenburg Stefan, Watzka Matthias, Clusmann Hans, Blümcke Ingmar, Bidlingmaier Frank, Elger Christian E, Stoffel-Wagner Birgit, Androgen receptor mRNA expression in the human hippocampus, Neuroscience Letters, 294, 1, 2000. Crossref
-
Weihua Zhang, Warner Margaret, Gustafsson Jan-Åke, Estrogen receptor beta in the prostate, Molecular and Cellular Endocrinology, 193, 1-2, 2002. Crossref
-
O’Keefe Denise S., Su Sai L., Bacich Dean J., Horiguchi Yutaka, Luo Ying, Powell C.Thomas, Zandvliet Dorothea, Russell Pamela J., Molloy Peter L., Nowak Norma J., Shows Thomas B., Mullins Cami, Vonder Haar Raymond A., Fair William R., Heston Warren D.W., Mapping, genomic organization and promoter analysis of the human prostate-specific membrane antigen gene, Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1443, 1-2, 1998. Crossref
-
Baez Javier, Kuang Yang, Mathematical Models of Androgen Resistance in Prostate Cancer Patients under Intermittent Androgen Suppression Therapy, Applied Sciences, 6, 11, 2016. Crossref
-
Durdiaková Jaroslava, Celec Peter, Androgen Regulation of Neural Circuit Activity: Molecules and Mechanisms, in Hormones, Brain and Behavior, 2017. Crossref
-
Weihua Zhang, Ekman Jenny, Almkvist Åsa, Saji Shigehira, Wang Ling, Warner Margaret, Gustafsson Jan-Åke, Involvement of Androgen Receptor in 17β-Estradiol-Induced Cell Proliferation in Rat Uterus1, Biology of Reproduction, 67, 2, 2002. Crossref
-
Ostrer H, Sex-based differences in gene transmission and gene expression, Lupus, 8, 5, 1999. Crossref
-
Roy A.K., Vellanoweth R.L., Chen S., Supakar P.C., Jung M.H., Song C.S., Chatterjee B., The evolutionary tangle of aging, sex, and reproduction and an experimental approach to its molecular dissection, Experimental Gerontology, 31, 1-2, 1996. Crossref
-
Ostrer Harry, Invited Review: Sex-based differences in gene expression, Journal of Applied Physiology, 91, 5, 2001. Crossref
-
Vitvitsky Victor, Prudova Anna, Stabler Sally, Dayal Sanjana, Lentz Steven R., Banerjee Ruma, Testosterone regulation of renal cystathionine β-synthase: implications for sex-dependent differences in plasma homocysteine levels, American Journal of Physiology-Renal Physiology, 293, 2, 2007. Crossref
-
Aikawa Katsuji, Asano Moriteru, Ono Koji, Habuka Noriyuki, Yano Jason, Wilson Keith, Fujita Hisashi, Kandori Hitoshi, Hara Takahito, Morimoto Megumi, Santou Takashi, Yamaoka Masuo, Nakayama Masaharu, Hasuoka Atsushi, Synthesis and biological evaluation of novel selective androgen receptor modulators (SARMs) Part III: Discovery of 4-(5-oxopyrrolidine-1-yl)benzonitrile derivative 2f as a clinical candidate, Bioorganic & Medicinal Chemistry, 25, 13, 2017. Crossref
-
Pelletier G., Effects of Estradiol on Prostate Epithelial Cells in the Castrated Rat, Journal of Histochemistry & Cytochemistry, 50, 11, 2002. Crossref
-
Zheng Rui, Samy T. S. Anantha, Schneider Christian P., Rue Loring W., Bland Kirby I., Chaudry Irshad H., Decreased 5α-dihydrotestosterone catabolism suppresses T lymphocyte functions in males after trauma-hemorrhage, American Journal of Physiology-Cell Physiology, 282, 6, 2002. Crossref
-
Gershon David, Dr. Arun Roy (1938–2003), Mechanisms of Ageing and Development, 124, 10-12, 2003. Crossref
-
Roy Arun K., Transcription Factors and Aging, Molecular Medicine, 3, 8, 1997. Crossref
-
Ji Qing, Chang Lilly, VanDenBerg David, Stanczyk Frank Z., Stolz Andrew, Selective reduction of AKR1C2 in prostate cancer and its role in DHT metabolism, The Prostate, 54, 4, 2003. Crossref
-
Cowin Prue A., Foster Paul M.D., Risbridger Gail P., Endocrine Disruption in the Male, in Endocrine-Disrupting Chemicals, 2007. Crossref
-
Rosinski-Chupin Isabelle, Huaulmé Jean-François, Rougeot Catherine, Rougeon François, The Transcriptional Response to Androgens of the Rat VCSA1 Gene Is Amplified by Both Binary and Graded Mechanisms, Endocrinology, 142, 10, 2001. Crossref
-
Samy T. S. A., Rue L. W., Chaudry I. H., Critical Role of Hormones in Traumatic Injury and Outcome, in Intensive Care Medicine, 2003. Crossref
-
Tanner Matthew J., Levina Elina, Shtutman Michael, Chen Mengqian, Ohouo Patrice, Buttyan Ralph, Unique Effects of Wnt Signaling on Prostate Cancer Cells: Modulation of the Androgen Signaling Pathway by Interactions of the Androgen Receptor Gene and Protein with Key Components of the Canonical Wnt Signaling Pathway, in Androgen Action in Prostate Cancer, 2009. Crossref
-
Du Yang, Weng Xiao-Dong, Wang Lei, Liu Xiu-Heng, Zhu Heng-Cheng, Guo Jia, Ning Jin-Zhuo, Xiao Cheng-Cheng, LncRNA XIST acts as a tumor suppressor in prostate cancer through sponging miR-23a to modulate RKIP expression, Oncotarget, 8, 55, 2017. Crossref
-
Tavassoli Peyman, Wafa Latif A., Cheng Helen, Zoubeidi Amina, Fazli Ladan, Gleave Martin, Snoek Robert, Rennie Paul S., TAF1 Differentially Enhances Androgen Receptor Transcriptional Activity via Its N-Terminal Kinase and Ubiquitin-Activating and -Conjugating Domains, Molecular Endocrinology, 24, 4, 2010. Crossref
-
Mohler Michael L., Bohl Casey E., Jones Amanda, Coss Christopher C., Narayanan Ramesh, He Yali, Hwang Dong Jin, Dalton James T., Miller Duane D., Nonsteroidal Selective Androgen Receptor Modulators (SARMs): Dissociating the Anabolic and Androgenic Activities of the Androgen Receptor for Therapeutic Benefit, Journal of Medicinal Chemistry, 52, 12, 2009. Crossref
-
Foster Paul M.D., Mcintyre Barry S., Endocrine Active Agents: Implications of Adverse and Non-Adverse Changes, Toxicologic Pathology, 30, 1, 2002. Crossref
-
Cao Hongwen, Wang Dan, Sun Peng, Chen Lei, Feng Yigeng, Gao Renjie, Zhoushi Qi Ling decoction represses docetaxel resistance and glycolysis of castration-resistant prostate cancer via regulation of SNHG10/miR-1271-5p/TRIM66 axis, Aging, 13, 19, 2021. Crossref
-
Huang Pengxiang, Chandra Vikas, Rastinejad Fraydoon, Structural Overview of the Nuclear Receptor Superfamily: Insights into Physiology and Therapeutics, Annual Review of Physiology, 72, 1, 2010. Crossref
-
Moisan Vanessa, Bomgardner Daniela, Tremblay Jacques J, Expression of the Ladybird-like homeobox 2 transcription factor in the developing mouse testis and epididymis, BMC Developmental Biology, 8, 1, 2008. Crossref
-
Claessens Frank, Alen Philippe, Devos Ann, Peeters Ben, Verhoeven Guido, Rombauts Wilfried, The Androgen-specific Probasin Response Element 2 Interacts Differentially with Androgen and Glucocorticoid Receptors, Journal of Biological Chemistry, 271, 32, 1996. Crossref
-
Verrijdt Guy, Schauwaers Kris, Haelens Annemie, Rombauts Wilfried, Claessens Frank, Functional Interplay between Two Response Elements with Distinct Binding Characteristics Dictates Androgen Specificity of the Mouse Sex-limited Protein Enhancer, Journal of Biological Chemistry, 277, 38, 2002. Crossref
-
Ning Yang-Min, Robins Diane M., AML3/CBFα1 Is Required for Androgen-specific Activation of the Enhancer of the Mouse Sex-limited Protein (Slp) Gene, Journal of Biological Chemistry, 274, 43, 1999. Crossref
-
Basrawala Z, Alimirah F, Xin H, Mohideen N, Campbell S C, Flanigan R C, Choubey D, Androgen receptor levels are increased by interferons in human prostate stromal and epithelial cells, Oncogene, 25, 19, 2006. Crossref
-
Chai Sergio C., Chen Taosheng, Nuclear Receptors, in Comprehensive Pharmacology, 2022. Crossref