Доступ предоставлен для: Guest
Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции
Critical Reviews™ in Eukaryotic Gene Expression
Импакт фактор: 1.841 5-летний Импакт фактор: 1.927 SJR: 0.649 SNIP: 0.516 CiteScore™: 1.96

ISSN Печать: 1045-4403
ISSN Онлайн: 2162-6502

Выпуски:
Том 29, 2019 Том 28, 2018 Том 27, 2017 Том 26, 2016 Том 25, 2015 Том 24, 2014 Том 23, 2013 Том 22, 2012 Том 21, 2011 Том 20, 2010 Том 19, 2009 Том 18, 2008 Том 17, 2007 Том 16, 2006 Том 15, 2005 Том 14, 2004 Том 13, 2003 Том 12, 2002 Том 11, 2001 Том 10, 2000 Том 9, 1999 Том 8, 1998 Том 7, 1997 Том 6, 1996 Том 5, 1995 Том 4, 1994

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.v5.i3-4.20
pages 219-253

Regulation and Regulatory Role of the Retinoids

Kong Wan Ng
Department of Medicine, The University of Melbourne, St Vincent's Hospital, Fitzroy 3065, Australia
Hong Zhou
Department of Medicine, The University of Melbourne, St Vincent's Hospital, Fitzroy 3065, Australia
Shehnaaz Manji
Department of Medicine, The University of Melbourne, St Vincent's Hospital, Fitzroy 3065, Australia
T. John Martin
St. Vincent's Institute of Medical Research and University of Melbourne Department of Medicine, Fitzroy, 3065, Victoria, Australia

Краткое описание

Retinoids regulate differentiation and cellular growth, exerting their physiological action by interacting with two families of nuclear receptors, the retinoic acid receptors (RARs), and the retinoid X receptors (RXRs), which regulate gene expression by forming transcriptionally active heterodimeric RAR/RXR or homodimeric RXR/RXR complexes on DNA. Although RAR/RXR heterodimers form preferentially in vitro and in vivo, it does not exclude the possibility that RXR/RXR homodimers may regulate a distinct signaling pathway. Synthetic retinoids that selectively activate or antagonize retinoic acid receptor isoforms promises to be useful tools for the elucidation of specific retinoid response pathways. Considerable progress has been made in understanding the molecular basis underlying limb bud formation, particularly the manner in which retinoic acid interacts with other signaling molecules to determine pattern formation. The phenotypic abnormalities observed in compound null mutants of retinoid receptors, recapitulating those described in the vitamin A deficiency syndrome, confirm the crucial function of endogenous retinoids in fetal development. However, the absence of phenotypic abnormalities in null mutants of individual RAR isoforms raises the possibility of functional redundancy among RAR subtypes and at the same time challenging the concept that the diverse effects of retinoids are related to the multiplicity of functionally distinct receptors.


Articles with similar content:

Retinoid-Regulated Gene Expression in Neural Development
Critical Reviews™ in Eukaryotic Gene Expression, Vol.7, 1997, issue 4
Margaret Clagett-Dame, Lori A. Plum
The Cbl Family of Signal Transduction Molecules
Critical Reviews™ in Oncogenesis, Vol.8, 1997, issue 4
Linda Smit , Jannie Borst
Retroviral Determinants of Leukemogenesis
Critical Reviews™ in Oncogenesis, Vol.5, 1994, issue 2-3
Cindi R. Starkey, Grace B. Athas, Laura S. Levy
Oncogenes and Signal Transduction Pathways Involved in the Regulation of Na+ Channel Expression
Critical Reviews™ in Oncogenesis, Vol.9, 1998, issue 1
Sadatoshi Tsuji, Shunsuke Sashihara, Takashi Matsui
Molecular Mechanisms Mediating Axon Pathway Formation
Critical Reviews™ in Eukaryotic Gene Expression, Vol.7, 1997, issue 1-2
Kristen M. Johansen, Jorgen Johansen