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ISSN Печать: 1045-4403
ISSN Онлайн: 2162-6502
Indexed in
Regulation of Amelogenin Gene Expression
Краткое описание
The X-chromosomal amelogenin gene is expressed at a high level by ameloblast cells within the enamel organ for a short time during tooth development. Therefore, expression is both tooth specific and developmentally regulated. A Y-chromosomal amelogenin gene is also active in human and cow, but has not been detected in mouse. Genes and/or cDNAs have been cloned for mouse, human, cow, rat, pig, opossum, and hamster, and analyses have indicated that coding and upstream regions are conserved across species. Alternative splicing is extensive and produces as many as 9 mRNAs from the 7 exon murine gene, resulting from single and multiple exon skipping and alternate 3' site selection within exon 6. The pattern of alternative splicing varies both between species and during development, which is expected to result in some diversity through varying complements of amelogenin proteins associated with this highly conserved gene.
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Li Yong, Suggs Cynthia, Wright J. Timothy, Yuan Zhi-an, Aragon Melissa, Fong Hanson, Simmons Darrin, Daly Bill, Golub Ellis E., Harrison Gerald, Kulkarni Ashok B., Gibson Carolyn W., Partial Rescue of the Amelogenin Null Dental Enamel Phenotype, Journal of Biological Chemistry, 283, 22, 2008. Crossref
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Li Xiao, Venugopalan Shankar R., Cao Huojun, Pinho Flavia O., Paine Michael L., Snead Malcolm L., Semina Elena V., Amendt Brad A., A model for the molecular underpinnings of tooth defects in Axenfeld–Rieger syndrome, Human Molecular Genetics, 23, 1, 2014. Crossref
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Gokulakrishnan Palanisamy, Kumar Rajiv Ranjan, Sharma Brahm Deo, Mendiratta Sanjod Kumar, Malav Omprakash, Sharma Deepak, Determination of Sex Origin of Meat and Meat Products on the DNA Basis: A Review, Critical Reviews in Food Science and Nutrition, 55, 10, 2015. Crossref
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Takahashi Ken, Shimonishi Mitsuru, Wang Rui, Watanabe Hiroatsu, Kikuchi Masahiko, Epithelial-mesenchymal interactions induce enamel matrix proteins and proteases in the epithelial cells of the rests of Malassez in vitro, European Journal of Oral Sciences, 120, 6, 2012. Crossref
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Gibson Carolyn W., Yuan Zhi-An, Hall Bradford, Longenecker Glenn, Chen Enhong, Thyagarajan Tamizchelvi, Sreenath Taduru, Wright J. Tim, Decker Sylvia, Piddington Ronald, Harrison Gerald, Kulkarni Ashok B., Amelogenin-deficient Mice Display an Amelogenesis Imperfecta Phenotype, Journal of Biological Chemistry, 276, 34, 2001. Crossref
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Moffatt Pierre, Smith Charles E., St-Arnaud René, Simmons Darrin, Wright J. Timothy, Nanci Antonio, Cloning of rat amelotin and localization of the protein to the basal lamina of maturation stage ameloblasts and junctional epithelium, Biochemical Journal, 399, 1, 2006. Crossref
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