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Critical Reviews™ in Eukaryotic Gene Expression

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ISSN Печать: 1045-4403

ISSN Онлайн: 2162-6502

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.6 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.2 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00058 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.33 SJR: 0.345 SNIP: 0.46 CiteScore™:: 2.5 H-Index: 67

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Warburg effect mechanism as the target for theoretical substantiation of new possibility cancer disease treatment

Том 21, Выпуск 1, 2011, pp. 13-28
DOI: 10.1615/CritRevEukarGeneExpr.v21.i1.20
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Краткое описание

Borrowing a method from the folk healers A. Omelchenko and R. Brois for the treatment of oncology patients, and having evaluated the positive results of their treatment method, the author explains and further substantiates this method using the concept of the Warburg effect. In addition, the effects on an organism of this treatment method were explored by the author on himself, and those outcomes are analyzed and described. Explanations of the mechanism of the presented method are provided from the points of view of biochemistry, physical chemistry, and biophysics, and also using the concept of the Warburg effect (most cancer cells predominantly produce energy by a high rate of glycolysis in the cytosol, rather than by a comparatively low rate of glycolysis followed by oxidation of pyruvate in mitochondria like most normal cells). The increase in lactic acid production is the necessary endoergonic mechanism for accumulation of energy required for huge anabolic processes in glycolysis metabolism and enormous consumption of energy for anabolic processes in cancer tissue, i.e. lactic acids accumulate energy for anabolic processes in cancer tissue metabolism2 (see section II). Prolonged medical starvation (42−45 days) for treatment of oncologic patients was used in the presented method. Following an explanation of the distinctions between the Warburg effect and other medical targets for treatment of cancer, the author substantiates theoretically the possibility of a new method of cancer disease treatment. The presented method of cancer treatment is also described in detail. Evaluations of the mechanisms of activity of some of the medical targets that are used in modern methods are given, also using the Warburg effect mechanism. In addition, the author suggests possible modes to integrate the presented method of treatment for cancer with modern cancer treatment methods, and encourages their pursuit following detailed clinical trials.

ЦИТИРОВАНО В
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  3. Sapandowski Anja, Stope Matthias, Evert Katja, Evert Matthias, Zimmermann Uwe, Peter Daniela, Päge Ilona, Burchardt Martin, Schild Lorenz, Cardiolipin composition correlates with prostate cancer cell proliferation, Molecular and Cellular Biochemistry, 410, 1-2, 2015. Crossref

  4. LIU LING, GONG LIANSHENG, ZHANG YANGDE, LI NIANFENG, Glycolysis in Panc-1 human pancreatic cancer cells is inhibited by everolimus, Experimental and Therapeutic Medicine, 5, 1, 2013. Crossref

  5. MO MIAO, PENG FENGHUA, WANG LU, PENG LONGKAI, LAN GONGBIN, YU SHAOJIE, Roles of mitochondrial transcription factor A and microRNA-590-3p in the development of bladder cancer, Oncology Letters, 6, 2, 2013. Crossref

  6. Mirzaei Seyed Abbas, Reiisi Somayeh, Ghiasi Tabari Parmida, Shekari Abolfazl, Aliakbari Fatemeh, Azadfallah Elaheh, Elahian Fatemeh, Broad blocking of MDR efflux pumps by acetylshikonin and acetoxyisovalerylshikonin to generate hypersensitive phenotype of malignant carcinoma cells, Scientific Reports, 8, 1, 2018. Crossref

  7. Liu Xuchun, Sun Gengyun, Shikonin enhances Adriamycin antitumor effects by inhibiting efflux pumps in A549 cells, Oncology Letters, 14, 4, 2017. Crossref

  8. Sadeghzadeh Masoud, Moldovan Rareş-Petru, Teodoro Rodrigo, Brust Peter, Wenzel Barbara, One-step radiosynthesis of the MCTs imaging agent [18F]FACH by aliphatic 18F-labelling of a methylsulfonate precursor containing an unprotected carboxylic acid group, Scientific Reports, 9, 1, 2019. Crossref

  9. Sadeghzadeh Masoud, Moldovan Rareş-Petru, Fischer Steffen, Wenzel Barbara, Ludwig Friedrich-Alexander, Teodoro Rodrigo, Deuther-Conrad Winnie, Jonnalagadda Shirisha, Jonnalagadda Sravan K., Gudelis Emilis, Šačkus Algirdas, Higuchi Kei, Ganapathy Vadivel, Mereddy Venkatram R., Drewes Lester R., Brust Peter, Development and radiosynthesis of the first 18 F-labeled inhibitor of monocarboxylate transporters (MCTs), Journal of Labelled Compounds and Radiopharmaceuticals, 62, 8, 2019. Crossref

  10. Sattler Bernhard, Kranz Mathias, Wenzel Barbara, Jain Nalin T., Moldovan Rareş-Petru, Toussaint Magali, Deuther-Conrad Winnie, Ludwig Friedrich-Alexander, Teodoro Rodrigo, Sattler Tatjana, Sadeghzadeh Masoud, Sabri Osama, Brust Peter, Preclinical Incorporation Dosimetry of [18F]FACH—A Novel 18F-Labeled MCT1/MCT4 Lactate Transporter Inhibitor for Imaging Cancer Metabolism with PET, Molecules, 25, 9, 2020. Crossref

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  12. Johar Dina, Elmehrath Ahmed O., Khalil Rania M., Elberry Mostafa H., Zaky Samy, Shalabi Samy A., Bernstein Larry H., Protein networks linking Warburg and reverse Warburg effects to cancer cell metabolism, BioFactors, 47, 5, 2021. Crossref

  13. Huang Yihong, Zheng Shuo, Lin Ying, Ke Liming, Circular RNA circ-ERBB2 Elevates the Warburg Effect and Facilitates Triple-Negative Breast Cancer Growth by the MicroRNA 136-5p/Pyruvate Dehydrogenase Kinase 4 Axis, Molecular and Cellular Biology, 41, 10, 2021. Crossref

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